1. NCCU Academic Hub
  2. Publications
  3. College of Science
  4. Periodical Articles
  5. Item

Publications-Periodical Articles

Article View/Open

Publication Export

Google ScholarTM

NCCU Library

Citation Infomation

Related Publications in TAIR

題名 Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior
作者 Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S.
王培育
Wang, Pei-Yu
貢獻者 神科所
關鍵詞 anti-Müllerian hormone; exploratory behavior; motor neuron; sexual dimorphism
日期 2009-04
上傳時間 21-Nov-2018 16:24:01 (UTC+8)
摘要 Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.
關聯 Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208
PMID: 19359476
資料類型 article
DOI https://doi.org/10.1073/pnas.0902253106
dc.contributor 神科所
dc.creator (作者) Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S.
dc.creator (作者) 王培育
dc.creator (作者) Wang, Pei-Yu
dc.date (日期) 2009-04
dc.date.accessioned 21-Nov-2018 16:24:01 (UTC+8)-
dc.date.available 21-Nov-2018 16:24:01 (UTC+8)-
dc.date.issued (上傳時間) 21-Nov-2018 16:24:01 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/120974-
dc.description.abstract (摘要) Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.en_US
dc.format.extent 757283 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208
dc.relation (關聯) PMID: 19359476
dc.subject (關鍵詞) anti-Müllerian hormone; exploratory behavior; motor neuron; sexual dimorphismen_US
dc.title (題名) Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavioren_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1073/pnas.0902253106
dc.doi.uri (DOI) https://doi.org/10.1073/pnas.0902253106