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題名 Semiparametric variance components models for genetic studies with longitudinal phenotypes
作者 Wang, Y.
黃佳慧
Huang, C.-H.
貢獻者 統計系
關鍵詞 Genome-wide linkage study ; Multivariate longitudinal data ; Penalized splines ; Quantitative trait locus
日期 2012-07
上傳時間 13-Aug-2019 09:19:19 (UTC+8)
摘要 In a family-based genetic study such as the Framingham Heart Study (FHS), longitudinal trait measurements are recorded on subjects collected from families. Observations on subjects from the same family are correlated due to shared genetic composition or environmental factors such as diet. The data have a 3-level structure with measurements nested in subjects and subjects nested in families. We propose a semiparametric variance components model to describe phenotype observed at a time point as the sum of a nonparametric population mean function, a nonparametric random quantitative trait locus (QTL) effect, a shared environmental effect, a residual random polygenic effect and measurement error. One feature of the model is that we do not assume a parametric functional form of the age-dependent QTL effect, and we use penalized spline-based method to fit the model. We obtain nonparametric estimation of the QTL heritability defined as the ratio of the QTL variance to the total phenotypic variance. We use simulation studies to investigate performance of the proposed methods and apply these methods to the FHS systolic blood pressure data to estimate age-specific QTL effect at 62cM on chromosome 17.
關聯 Biostatistics, Vol.13, pp.482-496
資料類型 article
DOI https://doi.org/10.1093/biostatistics/kxr027
dc.contributor 統計系
dc.creator (作者) Wang, Y.
dc.creator (作者) 黃佳慧
dc.creator (作者) Huang, C.-H.
dc.date (日期) 2012-07
dc.date.accessioned 13-Aug-2019 09:19:19 (UTC+8)-
dc.date.available 13-Aug-2019 09:19:19 (UTC+8)-
dc.date.issued (上傳時間) 13-Aug-2019 09:19:19 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/125126-
dc.description.abstract (摘要) In a family-based genetic study such as the Framingham Heart Study (FHS), longitudinal trait measurements are recorded on subjects collected from families. Observations on subjects from the same family are correlated due to shared genetic composition or environmental factors such as diet. The data have a 3-level structure with measurements nested in subjects and subjects nested in families. We propose a semiparametric variance components model to describe phenotype observed at a time point as the sum of a nonparametric population mean function, a nonparametric random quantitative trait locus (QTL) effect, a shared environmental effect, a residual random polygenic effect and measurement error. One feature of the model is that we do not assume a parametric functional form of the age-dependent QTL effect, and we use penalized spline-based method to fit the model. We obtain nonparametric estimation of the QTL heritability defined as the ratio of the QTL variance to the total phenotypic variance. We use simulation studies to investigate performance of the proposed methods and apply these methods to the FHS systolic blood pressure data to estimate age-specific QTL effect at 62cM on chromosome 17.
dc.format.extent 445661 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Biostatistics, Vol.13, pp.482-496
dc.subject (關鍵詞) Genome-wide linkage study ; Multivariate longitudinal data ; Penalized splines ; Quantitative trait locus
dc.title (題名) Semiparametric variance components models for genetic studies with longitudinal phenotypes
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1093/biostatistics/kxr027
dc.doi.uri (DOI) https://doi.org/10.1093/biostatistics/kxr027