| dc.contributor | 心理系 | - |
| dc.creator (作者) | 廖瑞銘 | - |
| dc.creator (作者) | Liao, Ruey-Ming | - |
| dc.creator (作者) | Teng, Ling-Ling | - |
| dc.creator (作者) | Lu, Guan-Ling | - |
| dc.creator (作者) | Chiou, Lih-Chu | - |
| dc.creator (作者) | Lin, Wei-Sheng | - |
| dc.date (日期) | 2019-04 | - |
| dc.date.accessioned | 21-Nov-2019 10:40:57 (UTC+8) | - |
| dc.date.available | 21-Nov-2019 10:40:57 (UTC+8) | - |
| dc.date.issued (上傳時間) | 21-Nov-2019 10:40:57 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/127386 | - |
| dc.description.abstract (摘要) | Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan—a precursor amino acid for serotonin biosynthesis in the brain—and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced longterm potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake. | - |
| dc.format.extent | 3528055 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | PLOS Biology, Vol.17, No.3, pp.e2007097 | - |
| dc.title (題名) | Serotonin receptor HTR6 mediates dietary restriction-induced memory enhancement | - |
| dc.type (資料類型) | article | - |
| dc.identifier.doi (DOI) | 10.1371/journal.pbio.2007097 | - |
| dc.doi.uri (DOI) | https://doi.org/10.1371/journal.pbio.2007097 | - |
