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| Title | Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan |
| Creator | 趙知章 Chao, Chih-Chang MH, Wu CW, Tsai DT*, Bau YW, Hung CL, Gong TC, Yueh SC, Wang YL, Lai SW, Hsu WS, Chang |
| Contributor | 神科所 |
| Key Words | Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism |
| Date | 2019-06 |
| Date Issued | 20-Feb-2020 11:56:01 (UTC+8) |
| Summary | BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. |
| Relation | Anticancer Research, Vol.39, No.6, pp.2791-2797 |
| Type | article |
| DOI | https://doi.org/10.21873/anticanres.13406 |
| dc.contributor | 神科所 | |
| dc.creator (作者) | 趙知章 | |
| dc.creator (作者) | Chao, Chih-Chang | |
| dc.creator (作者) | MH, Wu | |
| dc.creator (作者) | CW, Tsai | |
| dc.creator (作者) | DT*, Bau | |
| dc.creator (作者) | YW, Hung | |
| dc.creator (作者) | CL, Gong | |
| dc.creator (作者) | TC, Yueh | |
| dc.creator (作者) | SC, Wang | |
| dc.creator (作者) | YL, Lai | |
| dc.creator (作者) | SW, Hsu | |
| dc.creator (作者) | WS, Chang | |
| dc.date (日期) | 2019-06 | |
| dc.date.accessioned | 20-Feb-2020 11:56:01 (UTC+8) | - |
| dc.date.available | 20-Feb-2020 11:56:01 (UTC+8) | - |
| dc.date.issued (上傳時間) | 20-Feb-2020 11:56:01 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/128685 | - |
| dc.description.abstract (摘要) | BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. | |
| dc.format.extent | 108 bytes | - |
| dc.format.mimetype | text/html | - |
| dc.relation (關聯) | Anticancer Research, Vol.39, No.6, pp.2791-2797 | |
| dc.subject (關鍵詞) | Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism | |
| dc.title (題名) | Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.21873/anticanres.13406 | |
| dc.doi.uri (DOI) | https://doi.org/10.21873/anticanres.13406 |