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題名 Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan 作者 趙知章
Chao, Chih-Chang
MH, Wu
CW, Tsai
DT*, Bau
YW, Hung
CL, Gong
TC, Yueh
SC, Wang
YL, Lai
SW, Hsu
WS, Chang貢獻者 神科所 關鍵詞 Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism 日期 2019-06 上傳時間 20-Feb-2020 11:56:01 (UTC+8) 摘要 BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. 關聯 Anticancer Research, Vol.39, No.6, pp.2791-2797 資料類型 article DOI https://doi.org/10.21873/anticanres.13406 dc.contributor 神科所 dc.creator (作者) 趙知章 dc.creator (作者) Chao, Chih-Chang dc.creator (作者) MH, Wu dc.creator (作者) CW, Tsai dc.creator (作者) DT*, Bau dc.creator (作者) YW, Hung dc.creator (作者) CL, Gong dc.creator (作者) TC, Yueh dc.creator (作者) SC, Wang dc.creator (作者) YL, Lai dc.creator (作者) SW, Hsu dc.creator (作者) WS, Chang dc.date (日期) 2019-06 dc.date.accessioned 20-Feb-2020 11:56:01 (UTC+8) - dc.date.available 20-Feb-2020 11:56:01 (UTC+8) - dc.date.issued (上傳時間) 20-Feb-2020 11:56:01 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/128685 - dc.description.abstract (摘要) BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. dc.format.extent 108 bytes - dc.format.mimetype text/html - dc.relation (關聯) Anticancer Research, Vol.39, No.6, pp.2791-2797 dc.subject (關鍵詞) Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism dc.title (題名) Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan dc.type (資料類型) article dc.identifier.doi (DOI) 10.21873/anticanres.13406 dc.doi.uri (DOI) https://doi.org/10.21873/anticanres.13406
