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TitleContribution of caspase-8 genotypes to colorectal cancer risk in Taiwan
Creator趙知章
Chao, Chih-Chang
MH, Wu
CW, Tsai
DT*, Bau
YW, Hung
CL, Gong
TC, Yueh
SC, Wang
YL, Lai
SW, Hsu
WS, Chang
Contributor神科所
Key WordsCase–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism
Date2019-06
Date Issued20-Feb-2020 11:56:01 (UTC+8)
SummaryBACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.
RelationAnticancer Research, Vol.39, No.6, pp.2791-2797
Typearticle
DOI https://doi.org/10.21873/anticanres.13406
dc.contributor 神科所
dc.creator (作者) 趙知章
dc.creator (作者) Chao, Chih-Chang
dc.creator (作者) MH, Wu
dc.creator (作者) CW, Tsai
dc.creator (作者) DT*, Bau
dc.creator (作者) YW, Hung
dc.creator (作者) CL, Gong
dc.creator (作者) TC, Yueh
dc.creator (作者) SC, Wang
dc.creator (作者) YL, Lai
dc.creator (作者) SW, Hsu
dc.creator (作者) WS, Chang
dc.date (日期) 2019-06
dc.date.accessioned 20-Feb-2020 11:56:01 (UTC+8)-
dc.date.available 20-Feb-2020 11:56:01 (UTC+8)-
dc.date.issued (上傳時間) 20-Feb-2020 11:56:01 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/128685-
dc.description.abstract (摘要) BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.
dc.format.extent 108 bytes-
dc.format.mimetype text/html-
dc.relation (關聯) Anticancer Research, Vol.39, No.6, pp.2791-2797
dc.subject (關鍵詞) Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism
dc.title (題名) Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.21873/anticanres.13406
dc.doi.uri (DOI) https://doi.org/10.21873/anticanres.13406