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| Title | Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan |
| Creator | 趙知章 Chao, Chih-Chang Hsu, Shih-Wei Gong, Chi-Li Hsu, Huai-Mei Wang, Yun-Chi Chang, Wen-Shin Yueh-Ting Tsai, Liang-Chun Shih, Chia-Wen Tsai, DA-Tian Bau |
| Contributor | 神科所 |
| Key Words | Genotype; MMP2; Taiwan; metastasis; nasopharyngeal cancer; polymorphism; susceptibility |
| Date | 2019-07 |
| Date Issued | 27-May-2021 11:39:04 (UTC+8) |
| Summary | Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. |
| Relation | Cancer Genomics & Protemics, Vol.16, pp.287-292 |
| Type | article |
| DOI | https://doi.org/10.21873/cgp.20133 |
| dc.contributor | 神科所 | |
| dc.creator (作者) | 趙知章 | |
| dc.creator (作者) | Chao, Chih-Chang | |
| dc.creator (作者) | Hsu, Shih-Wei | |
| dc.creator (作者) | Gong, Chi-Li | |
| dc.creator (作者) | Hsu, Huai-Mei | |
| dc.creator (作者) | Wang, Yun-Chi | |
| dc.creator (作者) | Chang, Wen-Shin | |
| dc.creator (作者) | Yueh-Ting Tsai, Liang-Chun Shih, Chia-Wen Tsai, DA-Tian Bau | |
| dc.date (日期) | 2019-07 | |
| dc.date.accessioned | 27-May-2021 11:39:04 (UTC+8) | - |
| dc.date.available | 27-May-2021 11:39:04 (UTC+8) | - |
| dc.date.issued (上傳時間) | 27-May-2021 11:39:04 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/135217 | - |
| dc.description.abstract (摘要) | Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. | |
| dc.format.extent | 109960 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Cancer Genomics & Protemics, Vol.16, pp.287-292 | |
| dc.subject (關鍵詞) | Genotype; MMP2; Taiwan; metastasis; nasopharyngeal cancer; polymorphism; susceptibility | |
| dc.title (題名) | Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.21873/cgp.20133 | |
| dc.doi.uri (DOI) | https://doi.org/10.21873/cgp.20133 |