| dc.contributor | 神科所 | - |
| dc.creator (作者) | 詹銘煥 | - |
| dc.creator (作者) | Chan, Ming-Huan | - |
| dc.creator (作者) | Hsieh, Chung-Pin | - |
| dc.creator (作者) | Chang, Wei-Tang | - |
| dc.creator (作者) | Chen, Linyi | - |
| dc.creator (作者) | Chen, Hwei-Hsien | - |
| dc.date (日期) | 2021-07 | - |
| dc.date.accessioned | 27-Oct-2021 10:57:07 (UTC+8) | - |
| dc.date.available | 27-Oct-2021 10:57:07 (UTC+8) | - |
| dc.date.issued (上傳時間) | 27-Oct-2021 10:57:07 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/137550 | - |
| dc.description.abstract (摘要) | Objectives: The neuroprotective effects of resveratrol against excitatory neurotoxicity have been associated with N-methyl-D-aspartate receptor (NMDAR) inhibition. This study examined the differential inhibitory effects of resveratrol on NMDAR-mediated responses in neuronal cells with different NMDAR subtype composition. Methods: The effects of resveratrol on NMDA-induced cell death and calcium influx in immature and mature rat primary cortical neurons were determined and compared. Moreover, the potencies and efficacies of resveratrol to inhibit NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D NMDAR expressed in HEK 293 cells were evaluated. Results: Resveratrol significantly attenuated NMDA-induced cell death in mature neurons, but not in immature neurons. Resveratrol also concentration-dependently reduced NMDA-induced calcium influx among all NMDAR subtypes, but displayed NR2 subunit selectivity, with a potency rank order of NR2B = NR2D > NR2A = NR2C and an efficacy rank order of NR2B = NR2C > NR2A = NR2D. Data show the stronger inhibitory effects of resveratrol on NR1/NR2B than other subtypes. Moreover, resveratrol did not affect hippocampal long-term potentiation (LTP), but impaired long-term depression (LTD). Discussion: These findings reveal the specific NMDAR modulating profile of resveratrol, providing further insight into potential mechanisms underlying the protective effects of resveratrol on neurological disorders. | - |
| dc.format.extent | 2946916 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Nutritional Neuroscience, Vol.24, No.6, pp.443-458 | - |
| dc.title (題名) | Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes | - |
| dc.type (資料類型) | article | - |
| dc.identifier.doi (DOI) | 10.1080/1028415X.2019.1641995 | - |
| dc.doi.uri (DOI) | https://doi.org/10.1080/1028415X.2019.1641995 | - |
