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題名 Comparative effects of cannabinoid CB1 receptor agonist and antagonist on timing impulsivity induced by d-amphetamine in a differential reinforcement of low-rate response task in male rats
作者 廖瑞銘
Liao, Ruey-Ming
Chuang, Chuen-Yu;Lu, Xi-Yun;Hsu, Wei-Chung;Chen, Shuo-Fu
貢獻者 心理系
關鍵詞 Cannabinoid psychopharmacology; Operant behavior; Psychostimulants; SR141716A (rimonabant); Timing impulsivity; WIN55,212–2
日期 2021-11
上傳時間 24-Jun-2022 15:28:25 (UTC+8)
摘要 Rationale: In human beings and experimental animals, maladaptive impulsivity is manifested by the acute injection of psychostimulants, such as amphetamine. Cannabinoid CB1 receptors have been implicated in the regulation of stimulant-induced impulsive action, but the role of CB1 receptors in timing-related impulsive action by amphetamine remains unknown.

Methods: Male rats were used in evaluating the effects of CB1 receptor antagonist and agonist (SR141716A and WIN55,212–2, respectively) systemically administered individually and combined with d-amphetamine on a differential reinforcement of low-rate response (DRL) task, an operant behavioral test of timing and behavioral inhibition characterized as a type of timing impulsive action.

Results: A distinct pattern of DRL behavioral changes was produced by acute d-amphetamine (0, 0.5, 1.0, and 1.5 mg/kg) treatment in a dose-dependent fashion, whereas no significant dose effect was detected for acute SR141716A (0, 0.3, 1, and 3 mg/kg) or WIN55,212–2 (0, 0.5, 1, and 2 mg/kg) treatment. Furthermore, DRL behavior altered by 1.5 mg/kg d-amphetamine was reversed by a noneffective dose of SR141716A (3 mg/kg) pretreatment. The minimally influenced DRL behavior by 0.5 mg/kg d-amphetamine was affected by pretreatment with a noneffective dose of WIN55,212–2 (1 mg/kg).

Conclusion: These findings reveal that the activation and blockade of CB1 receptors can differentially modulate the timing impulsive action of DRL behavior induced by acute amphetamine treatment. Characterizing how CB1 receptors modulate impulsive behavior will deepen our understanding of the cannabinoid psychopharmacology of impulsivity and may be helpful in developing an optimal pharmacotherapy for reducing maladaptive impulsivity in patients with some psychiatric disorders.
關聯 Psychopharmacology, 239, 1459-1473
資料類型 article
DOI https://doi.org/10.1007/s00213-021-06018-z
dc.contributor 心理系
dc.creator (作者) 廖瑞銘
dc.creator (作者) Liao, Ruey-Ming
dc.creator (作者) Chuang, Chuen-Yu;Lu, Xi-Yun;Hsu, Wei-Chung;Chen, Shuo-Fu
dc.date (日期) 2021-11
dc.date.accessioned 24-Jun-2022 15:28:25 (UTC+8)-
dc.date.available 24-Jun-2022 15:28:25 (UTC+8)-
dc.date.issued (上傳時間) 24-Jun-2022 15:28:25 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/140385-
dc.description.abstract (摘要) Rationale: In human beings and experimental animals, maladaptive impulsivity is manifested by the acute injection of psychostimulants, such as amphetamine. Cannabinoid CB1 receptors have been implicated in the regulation of stimulant-induced impulsive action, but the role of CB1 receptors in timing-related impulsive action by amphetamine remains unknown.

Methods: Male rats were used in evaluating the effects of CB1 receptor antagonist and agonist (SR141716A and WIN55,212–2, respectively) systemically administered individually and combined with d-amphetamine on a differential reinforcement of low-rate response (DRL) task, an operant behavioral test of timing and behavioral inhibition characterized as a type of timing impulsive action.

Results: A distinct pattern of DRL behavioral changes was produced by acute d-amphetamine (0, 0.5, 1.0, and 1.5 mg/kg) treatment in a dose-dependent fashion, whereas no significant dose effect was detected for acute SR141716A (0, 0.3, 1, and 3 mg/kg) or WIN55,212–2 (0, 0.5, 1, and 2 mg/kg) treatment. Furthermore, DRL behavior altered by 1.5 mg/kg d-amphetamine was reversed by a noneffective dose of SR141716A (3 mg/kg) pretreatment. The minimally influenced DRL behavior by 0.5 mg/kg d-amphetamine was affected by pretreatment with a noneffective dose of WIN55,212–2 (1 mg/kg).

Conclusion: These findings reveal that the activation and blockade of CB1 receptors can differentially modulate the timing impulsive action of DRL behavior induced by acute amphetamine treatment. Characterizing how CB1 receptors modulate impulsive behavior will deepen our understanding of the cannabinoid psychopharmacology of impulsivity and may be helpful in developing an optimal pharmacotherapy for reducing maladaptive impulsivity in patients with some psychiatric disorders.
dc.format.extent 106 bytes-
dc.format.mimetype text/html-
dc.relation (關聯) Psychopharmacology, 239, 1459-1473
dc.subject (關鍵詞) Cannabinoid psychopharmacology; Operant behavior; Psychostimulants; SR141716A (rimonabant); Timing impulsivity; WIN55,212–2
dc.title (題名) Comparative effects of cannabinoid CB1 receptor agonist and antagonist on timing impulsivity induced by d-amphetamine in a differential reinforcement of low-rate response task in male rats
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1007/s00213-021-06018-z
dc.doi.uri (DOI) https://doi.org/10.1007/s00213-021-06018-z