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題名 前額葉皮質次級腦區的破壞對區辨性低反應頻率之操作制約行為的影響效果
Lesion effects of prefrontal cortex subareas on operant behavior trained by differential reinforcement of low-rate response schedule
作者 吳姝儀
Wu, Shu-Yi
貢獻者 楊立行
Lee, Xieng Yang
吳姝儀
Wu, Shu-Yi
關鍵詞 操作式制約行為
鵝膏蕈酸
眼眶前額葉皮質
內側前額葉皮質
習得歷程
日期 2023
上傳時間 1-Feb-2023 14:15:29 (UTC+8)
摘要 區辨性低反應頻率增強模式操作式行為作業 (Differential Reinforcement of Low-rate Response task; DRL) 中，其制約反應的建構歷程被認為需有適當的時間計時與行為抑制兩種能力。過去的心理藥理學實驗的結果顯示，一些精神性藥物對於大鼠受試的DRL表現有所影響，然而，該行為本身或其受到藥物影響所涉及的腦部神經機制不明有待釐清。前額葉皮質的主要認知功能包含行為抑制，因此本研究將以大鼠前額葉皮質腦區為目標，利用鵝膏蕈酸 (ibotenic acid) 破壞外側眼眶前額葉 ( lateral orbital frontal cortex; lOFC) 或（和）內側前額葉 (medial frontal cortex; mPFC) 的實驗操弄，探討DRL行為在不同的學習及表現歷程的影響效果。基於制約行為的習得與表現兩階段之神經機制不同的假說，本研究將腦區破壞分別操弄在學習前與學習後兩個不同時間點，以探測lOFC及mPFC對DRL行為的習得及表現所扮演的角色。實驗一操弄破壞大鼠兩側的lOFC或mPFC，檢測這兩個腦區各自對於DRL行為的習得與表現的影響。結果發現，mPFC破壞組在DRL行為消除階段比控制組快，而lOFC破壞組較控制組不衝動。實驗二則進行同時破壞大鼠兩側的lOFC和mPFC，以檢測其對於DRL行為習得的影響。結果顯示同時破壞兩側的lOFC與mPFC會影響DRL的習得歷程，且較控制組衝動。本研究結果發現，mPFC與lOFC兩腦區有共同參與調控計時能力與衝動抑制的功能。綜合以上結果，mPFC會參與消除的學習，而lOFC在區間計時的功能上則扮演重要的角色。
Operant response maintained on a differential reinforcement of low-rate responding (DRL) schedule of reinforcement requires optimal timing control and behavioral inhibition ability. DRL behavior has been shown to be affected by psychoactive drugs from psychopharmacology research. However, the underlying neural mechanisms of this operant behavior remained unknown. In this project, two subareas of prefrontal cortex including the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC) will be examined by pharmacological lesion approach. Based on the hypothesis that the neural mechanisms of the two stages of the acquisition and performance of the conditioning behavior are different, the aim of the present study was to clarify the role of the mPFC or lOFC at two different time points before learning and after learning by investigating the effect of ibotenic acid induced lesions of the prefrontal subareas on DRL task. Experiment 1 manipulated bilateral mPFC or lOFC in rats to investigate the effects of these brain subregions on acquisition or performance on DRL tasks, respectively. Animals with bilateral mPFC lesions learned faster than control group in the extinction phase, while the lOFC lesioned group was less impulsive than control group. In experiment 2, the two regions of mPFC and lOFC lesions bilaterally in the rats to estimate its effect on DRL acquisition. The results show that lesions bilateral mPFC and lOFC simultaneously would affect acquisition process of DRL, and induced impulsive behavior in lesion group. These data suggest that both mPFC and lOFC are involved in the regulation of timing processes and impulsive inhibition. Taken together, the mPFC lesion affected response in the behavioral extinction, implying mPFC may involve in this process; lOFC lesion yielded behavioral changes to less impulsive in the DRL task with interval upward shifting in the acquisition and preference phases, showing lOFC may participate in the timing process.
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描述 碩士
國立政治大學
心理學系
109752010
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0109752010
資料類型 thesis
dc.contributor.advisor 楊立行zh_TW
dc.contributor.advisor Lee, Xieng Yangen_US
dc.contributor.author (Authors) 吳姝儀zh_TW
dc.contributor.author (Authors) Wu, Shu-Yien_US
dc.creator (作者) 吳姝儀zh_TW
dc.creator (作者) Wu, Shu-Yien_US
dc.date (日期) 2023en_US
dc.date.accessioned 1-Feb-2023 14:15:29 (UTC+8)-
dc.date.available 1-Feb-2023 14:15:29 (UTC+8)-
dc.date.issued (上傳時間) 1-Feb-2023 14:15:29 (UTC+8)-
dc.identifier (Other Identifiers) G0109752010en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/143199-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 心理學系zh_TW
dc.description (描述) 109752010zh_TW
dc.description.abstract (摘要) 區辨性低反應頻率增強模式操作式行為作業 (Differential Reinforcement of Low-rate Response task; DRL) 中，其制約反應的建構歷程被認為需有適當的時間計時與行為抑制兩種能力。過去的心理藥理學實驗的結果顯示，一些精神性藥物對於大鼠受試的DRL表現有所影響，然而，該行為本身或其受到藥物影響所涉及的腦部神經機制不明有待釐清。前額葉皮質的主要認知功能包含行為抑制，因此本研究將以大鼠前額葉皮質腦區為目標，利用鵝膏蕈酸 (ibotenic acid) 破壞外側眼眶前額葉 ( lateral orbital frontal cortex; lOFC) 或（和）內側前額葉 (medial frontal cortex; mPFC) 的實驗操弄，探討DRL行為在不同的學習及表現歷程的影響效果。基於制約行為的習得與表現兩階段之神經機制不同的假說，本研究將腦區破壞分別操弄在學習前與學習後兩個不同時間點，以探測lOFC及mPFC對DRL行為的習得及表現所扮演的角色。實驗一操弄破壞大鼠兩側的lOFC或mPFC，檢測這兩個腦區各自對於DRL行為的習得與表現的影響。結果發現，mPFC破壞組在DRL行為消除階段比控制組快，而lOFC破壞組較控制組不衝動。實驗二則進行同時破壞大鼠兩側的lOFC和mPFC，以檢測其對於DRL行為習得的影響。結果顯示同時破壞兩側的lOFC與mPFC會影響DRL的習得歷程，且較控制組衝動。本研究結果發現，mPFC與lOFC兩腦區有共同參與調控計時能力與衝動抑制的功能。綜合以上結果，mPFC會參與消除的學習，而lOFC在區間計時的功能上則扮演重要的角色。zh_TW
dc.description.abstract (摘要) Operant response maintained on a differential reinforcement of low-rate responding (DRL) schedule of reinforcement requires optimal timing control and behavioral inhibition ability. DRL behavior has been shown to be affected by psychoactive drugs from psychopharmacology research. However, the underlying neural mechanisms of this operant behavior remained unknown. In this project, two subareas of prefrontal cortex including the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC) will be examined by pharmacological lesion approach. Based on the hypothesis that the neural mechanisms of the two stages of the acquisition and performance of the conditioning behavior are different, the aim of the present study was to clarify the role of the mPFC or lOFC at two different time points before learning and after learning by investigating the effect of ibotenic acid induced lesions of the prefrontal subareas on DRL task. Experiment 1 manipulated bilateral mPFC or lOFC in rats to investigate the effects of these brain subregions on acquisition or performance on DRL tasks, respectively. Animals with bilateral mPFC lesions learned faster than control group in the extinction phase, while the lOFC lesioned group was less impulsive than control group. In experiment 2, the two regions of mPFC and lOFC lesions bilaterally in the rats to estimate its effect on DRL acquisition. The results show that lesions bilateral mPFC and lOFC simultaneously would affect acquisition process of DRL, and induced impulsive behavior in lesion group. These data suggest that both mPFC and lOFC are involved in the regulation of timing processes and impulsive inhibition. Taken together, the mPFC lesion affected response in the behavioral extinction, implying mPFC may involve in this process; lOFC lesion yielded behavioral changes to less impulsive in the DRL task with interval upward shifting in the acquisition and preference phases, showing lOFC may participate in the timing process.en_US
dc.description.tableofcontents 第一章、緒論 1
一、前言 1
二、前額葉皮質的執行功能 1
三、衝動特質的類別 3
四、區辨性增強低頻反應作業 4
五、5-choice serial reaction time task (5-CSRTT) 5
六、研究目的 6
第二章、實驗材料與方法 8
一、受試者 8
二、實驗儀器 8
三、腦部破壞手術 9
四、藥物 10
五、操作式DRL行為訓練 10
六、實驗設計 11
（一）實驗1-1：破壞雙側lOFC或mPFC在DRL的習得階段 11
（二）實驗1-2：破壞雙側lOFC或mPFC在DRL的表現階段 12
（三）實驗2：破壞雙側lOFC與mPFC在DRL的習得階段 12
七、組織學檢驗 12
八、統計分析 13
第三章、統計結果 14
一、實驗1-1：破壞雙側OFC或mPFC在DRL對習得階段的影響 14
mPFC 14
（一）、DRL-10行為習得階段 14
（二）、DRL-15行為習得階段 14
（三）、DRL-15行為消除階段 15
（四）、DRL-15行為回復階段 15
lOFC 16
（一）、DRL-10行為習得階段 16
（二）、DRL-15行為習得階段 16
（三）、DRL-15行為消除階段 17
（四）、DRL-15行為回復階段 17
二、實驗1-2：破壞雙側lOFC或mPFC在DRL的表現階段 18
三、實驗2：破壞雙側lOFC與mPFC在DRL的習得階段 19
（一） DRL-10行為習得階段 19
（二） DRL-15行為習得階段 20
（三） DRL-15行為消除階段 22
（四） DRL-15行為回復階段 22
第四章、綜合討論 24
一、 mPFC對於DRL行為各個階段的探討 24
二、 OFC對於DRL行為各個階段的探討 26
三、 PFC對於DRL行為各個階段的探討 28
四、雙側破壞lOFC或mPFC對計時能力的影響 29
五、lOFC或mPFC在DRL習得歷程中的角色 31
六、結論 31
第五章、參考文獻 33		zh_TW
dc.format.extent 3713054 bytes-
dc.format.mimetype application/pdf-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0109752010en_US
dc.subject (關鍵詞) 操作式制約行為zh_TW
dc.subject (關鍵詞) 鵝膏蕈酸zh_TW
dc.subject (關鍵詞) 眼眶前額葉皮質zh_TW
dc.subject (關鍵詞) 內側前額葉皮質zh_TW
dc.subject (關鍵詞) 習得歷程zh_TW
dc.title (題名) 前額葉皮質次級腦區的破壞對區辨性低反應頻率之操作制約行為的影響效果zh_TW
dc.title (題名) Lesion effects of prefrontal cortex subareas on operant behavior trained by differential reinforcement of low-rate response scheduleen_US
dc.type (資料類型) thesisen_US
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