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題名 額葉紋狀體與額葉海馬體迴路功能性破壞對區辨性增強低頻反應操作式制約行為的影響
Effects of fronto-striatal and fronto-hippocampal functional disconnection on operant behavior trained by differential reinforcement of low-rate response schedule
作者 吳舒婷
Wu, Shu-Ting
貢獻者 楊立行
Yang, Lee-Xieng
吳舒婷
Wu, Shu-Ting
關鍵詞 操作式制約行為
功能性連結破壞
鵝膏蕈酸
額葉紋狀體
額葉海馬體
日期 2023
上傳時間 3-Oct-2023 10:46:11 (UTC+8)
摘要 在大腦掌管的高階認知功能中，前額葉、紋狀體，和海馬迴等多個腦區共 同針對衝動控制和時間感知這兩個功能扮演著重要角色。而在操作式制約行為 中，區辨性低反應頻率增強模式作業 (Differential Reinforcement of Low-rate Response task; DRL)被認為需要涉及上述兩個認知歷程。然而，過去對於此些腦 區的研究主要是使用消融、興奮性毒素破壞、或藥理方式所進行單一或雙側破 壞腦區的方式，很少有研究運用功能性連結破壞的方法探索衝動行為的神經機 制。本研究透過功能性連結破壞方法探討前額葉中兩個子腦區的連結、前額葉- 紋狀體、前額葉-伏隔核，和前額葉-海馬迴的神經連結機制對 DRL 衝動行為的 影響。實驗 1 針對外側眼眶前額葉(lateral orbitofrontal cortex; lOFC)與內側前 額葉(medial prefrontal cortex; mPFC)之間的功能聯繫進行破壞。實驗 2 則針 對外側眼眶前額葉與基底核或海馬迴進行功能性破壞。實驗 2-1 針對 lOFC 與背 側紋狀體(dorsal striatum; DS)，實驗 2-2 為 lOFC 與伏隔核(Nucleus accumbens; NAc)，以及實驗 2-3 為 lOFC 和海馬迴(Hippocampus; HIP)等三連結進行功能性破壞。實驗 3 則針對 mPFC 與 NAc 之間的連接進行了功能性破壞。然而，因連結破壞的實驗方式可能在學習階段的不同時間發生，因此本研 究測量了學習的不同階段，包含 DRL 10 秒與 DRL 15 秒的習得，DRL 15 秒消 除，與 DRL 15 秒再習得。研究結果顯示，在針對 lOFC-DS 連接迴路操弄的實 驗中，功能性破壞組在再習得階段的表現優於實驗控制組，其他階段則無此影 響。而在針對 lOFC-NAc 連接迴路操弄的實驗中，功能性破壞組則在習得 DRL 10 秒與 DRL 15 秒的表現較控制組差。然而在針對 lOFC-mPFC、lOFC-HIP 和 mPFC-NAc 這三個迴路操弄的研究中沒有組間的差異。綜合以上結果，實驗支 持皮質-紋狀體間的神經網絡參與衝動行為，並有助於實驗者對不同學習階段的 DRL 作業在行為抑制相關的時間感知中進行更深入的了解。
In the brain, the prefrontal, striatal, and hippocampal areas together are important for high-level cognition functions, including impulsive control and timing. Operant behavior trained by differential reinforcement of low-rate response (DRL) schedule of reinforcement requires these two processes. Previous studies investigated the functions of these brain areas using aspiration, excitotoxic lesion, or pharmacological treatment mainly through a manner of bilateral interventions, few studies applied the functional disconnection approach to explore the neural substrates of impulsive action. This study evaluated the roles of fronto-striatal and fronto-hippocampal circuits on DRL behavior via the approach of functional disconnection. Experiment 1 manipulated the functional disconnection between the lateral orbitofrontal cortex (lOFC) and medial prefrontal cortex (mPFC). Experiment 2 intervened the lOFC connecting to the dorsal striatum (DS; Experiment 2-1), to the nucleus accumbens (NAc; Experiment 2-2), and to the hippocampus (HIP; Experiment 2-3). And, Experiment 3 manipulated the functional disconnection between the mPFC and NAc. In consideration of the potential impacts of disconnection lesions that could affect distinct processes in different learning stages. Behavioral assessments were conducted in the acquisition of DRL 10s and DRL 15s which were followed by the extinction and spontaneous recovery. The results showed that rats with disconnection lesions of lOFC-DS performed better in the recovery stage than those with control lesions, but had no impact on the other stages. Moreover, rats with disconnection lesions of lOFC- NAc disrupted the acquisition of DRL 10s and DRL 15s. No significant influence was produced by the functional disconnection of lOFC-mPFC, lOFC-HIP, or mPFC-NAc. Together, the current data are in general agreement with the notion of the cortico- striatal circuit involved in impulsive action and provide insights of timing associated with behavioral inhibition in the acquisition of DRL behavior at different learning stages.
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描述 碩士
國立政治大學
心理學系
110752011
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0110752011
資料類型 thesis
dc.contributor.advisor 楊立行zh_TW
dc.contributor.advisor Yang, Lee-Xiengen_US
dc.contributor.author (Authors) 吳舒婷zh_TW
dc.contributor.author (Authors) Wu, Shu-Tingen_US
dc.creator (作者) 吳舒婷zh_TW
dc.creator (作者) Wu, Shu-Tingen_US
dc.date (日期) 2023en_US
dc.date.accessioned 3-Oct-2023 10:46:11 (UTC+8)-
dc.date.available 3-Oct-2023 10:46:11 (UTC+8)-
dc.date.issued (上傳時間) 3-Oct-2023 10:46:11 (UTC+8)-
dc.identifier (Other Identifiers) G0110752011en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/147738-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 心理學系zh_TW
dc.description (描述) 110752011zh_TW
dc.description.abstract (摘要) 在大腦掌管的高階認知功能中，前額葉、紋狀體，和海馬迴等多個腦區共 同針對衝動控制和時間感知這兩個功能扮演著重要角色。而在操作式制約行為 中，區辨性低反應頻率增強模式作業 (Differential Reinforcement of Low-rate Response task; DRL)被認為需要涉及上述兩個認知歷程。然而，過去對於此些腦 區的研究主要是使用消融、興奮性毒素破壞、或藥理方式所進行單一或雙側破 壞腦區的方式，很少有研究運用功能性連結破壞的方法探索衝動行為的神經機 制。本研究透過功能性連結破壞方法探討前額葉中兩個子腦區的連結、前額葉- 紋狀體、前額葉-伏隔核，和前額葉-海馬迴的神經連結機制對 DRL 衝動行為的 影響。實驗 1 針對外側眼眶前額葉(lateral orbitofrontal cortex; lOFC)與內側前 額葉(medial prefrontal cortex; mPFC)之間的功能聯繫進行破壞。實驗 2 則針 對外側眼眶前額葉與基底核或海馬迴進行功能性破壞。實驗 2-1 針對 lOFC 與背 側紋狀體(dorsal striatum; DS)，實驗 2-2 為 lOFC 與伏隔核(Nucleus accumbens; NAc)，以及實驗 2-3 為 lOFC 和海馬迴(Hippocampus; HIP)等三連結進行功能性破壞。實驗 3 則針對 mPFC 與 NAc 之間的連接進行了功能性破壞。然而，因連結破壞的實驗方式可能在學習階段的不同時間發生，因此本研 究測量了學習的不同階段，包含 DRL 10 秒與 DRL 15 秒的習得，DRL 15 秒消 除，與 DRL 15 秒再習得。研究結果顯示，在針對 lOFC-DS 連接迴路操弄的實 驗中，功能性破壞組在再習得階段的表現優於實驗控制組，其他階段則無此影 響。而在針對 lOFC-NAc 連接迴路操弄的實驗中，功能性破壞組則在習得 DRL 10 秒與 DRL 15 秒的表現較控制組差。然而在針對 lOFC-mPFC、lOFC-HIP 和 mPFC-NAc 這三個迴路操弄的研究中沒有組間的差異。綜合以上結果，實驗支 持皮質-紋狀體間的神經網絡參與衝動行為，並有助於實驗者對不同學習階段的 DRL 作業在行為抑制相關的時間感知中進行更深入的了解。zh_TW
dc.description.abstract (摘要) In the brain, the prefrontal, striatal, and hippocampal areas together are important for high-level cognition functions, including impulsive control and timing. Operant behavior trained by differential reinforcement of low-rate response (DRL) schedule of reinforcement requires these two processes. Previous studies investigated the functions of these brain areas using aspiration, excitotoxic lesion, or pharmacological treatment mainly through a manner of bilateral interventions, few studies applied the functional disconnection approach to explore the neural substrates of impulsive action. This study evaluated the roles of fronto-striatal and fronto-hippocampal circuits on DRL behavior via the approach of functional disconnection. Experiment 1 manipulated the functional disconnection between the lateral orbitofrontal cortex (lOFC) and medial prefrontal cortex (mPFC). Experiment 2 intervened the lOFC connecting to the dorsal striatum (DS; Experiment 2-1), to the nucleus accumbens (NAc; Experiment 2-2), and to the hippocampus (HIP; Experiment 2-3). And, Experiment 3 manipulated the functional disconnection between the mPFC and NAc. In consideration of the potential impacts of disconnection lesions that could affect distinct processes in different learning stages. Behavioral assessments were conducted in the acquisition of DRL 10s and DRL 15s which were followed by the extinction and spontaneous recovery. The results showed that rats with disconnection lesions of lOFC-DS performed better in the recovery stage than those with control lesions, but had no impact on the other stages. Moreover, rats with disconnection lesions of lOFC- NAc disrupted the acquisition of DRL 10s and DRL 15s. No significant influence was produced by the functional disconnection of lOFC-mPFC, lOFC-HIP, or mPFC-NAc. Together, the current data are in general agreement with the notion of the cortico- striatal circuit involved in impulsive action and provide insights of timing associated with behavioral inhibition in the acquisition of DRL behavior at different learning stages.en_US
dc.description.tableofcontents CHAPTER 1: INTRODUCTION 1
IMPULSIVITY 1
THE DRL BEHA VIOR 2
THE 5-CSRTT AND SSRT 3
BRAIN AREAS ASSOCIATED WITH IMPULSIVE ACTION 5
The PFC subregions 5
Striatal subregions 7
Hippocampus 8
FUNCTIONAL DISCONNECTION APPROACH WITH EXCITOTOXIC LESION 9
HYPOTHESES 11

CHAPTER 2: MATERIALS AND METHODS 13
SUBJECTS 13
STEREOTAXIC SURGERY FOR IBOTENATE LESION 13
APPARATUS 15
PROCEDURES OF BEHAVIORAL TESTS 16
EXPERIMENTAL PROTOCOLS 17
Experiment 1: Effects of functional disconnection of the lOFC and mPFC 17
Experiment 2-1: Effects of functional disconnection of the lOFC and DS 17
Experiment 2-2: Effects of functional disconnection of the lOFC and NAc 18
Experiment 2-3: Effects of functional disconnection of the lOFC and HIP 18
Experiment 3: Effects of functional disconnection of mPFC and NAc 18
HISTOLOGY 19
DATA COLLECTION AND STATISTICAL ANALYSIS 19
CHAPTER 3: RESULTS 21
EXPERIMENT 1: EFFECTS OF FUNCTIONAL DISCONNECTION OF THE LOFC AND MPFC 21
The acquisition of DRL 10-s behavior 21
The acquisition of DRL 15-s behavior 21
The extinction of DRL 15-s behavior 22
The recovery of DRL 15-s behavior after extinction 22
EXPERIMENT 2-1: EFFECTS OF FUNCTIONAL DISCONNECTION OF THE LOFC AND DS 22
The acquisition of DRL 10-s behavior 23
The acquisition of DRL 15-s behavior 23
The extinction of DRL 15-s behavior 24
The recovery of DRL 15-s after extinction 24
EXPERIMENT 2-2: EFFECTS OF FUNCTIONAL DISCONNECTION OF THE LOFC AND NAC 25
The acquisition of DRL 10-s behavior 25
The acquisition of DRL 15-s behavior 26
The extinction of DRL 15-s behavior 26
The recovery of DRL 15-s after extinction 26
EXPERIMENT 2-3: EFFECTS OF FUNCTIONAL DISCONNECTION OF THE LOFC AND HIP 27
The acquisition of DRL 10-s behavior 27
The acquisition of DRL 15-s behavior 28
The extinction of DRL 15-s behavior 28
The recovery of DRL 15-s behavior after extinction 29
EXPERIMENT 3: EFFECTS OF FUNCTIONAL DISCONNECTION OF THE MPFC AND NAC 29
The acquisition of DRL 10-s behavior 29
The acquisition of DRL 15-s behavior 30
The extinction of DRL 15-s 30
The recovery of DRL 15-s after extinction 30
RESULTS OF THE LOCOMOTOR ACTIVITY 31
CHAPTER 4: DISCUSSION 32
LACK OF BEHAVIORAL CHANGES ON DRL TASK FOLLOWING THE MPFC-LOFC DISCONNECTION 32
BEHAVIORAL EFFECTS OF CORTICO-STRIATAL DISCONNECTION 33
BEHAVIORAL EFFECTS OF CORTICO-HIPPOCAMPAL DISCONNECTION 35
LIMITATIONS 36
CONCLUSION 38
CHAPTER 5: REFERENCES 39
FIGURES 51		zh_TW
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dc.format.mimetype application/pdf-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0110752011en_US
dc.subject (關鍵詞) 操作式制約行為zh_TW
dc.subject (關鍵詞) 功能性連結破壞zh_TW
dc.subject (關鍵詞) 鵝膏蕈酸zh_TW
dc.subject (關鍵詞) 額葉紋狀體zh_TW
dc.subject (關鍵詞) 額葉海馬體zh_TW
dc.title (題名) 額葉紋狀體與額葉海馬體迴路功能性破壞對區辨性增強低頻反應操作式制約行為的影響zh_TW
dc.title (題名) Effects of fronto-striatal and fronto-hippocampal functional disconnection on operant behavior trained by differential reinforcement of low-rate response scheduleen_US
dc.type (資料類型) thesisen_US
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