| dc.contributor | 應物所 | |
| dc.creator (作者) | 蔡尚岳 | |
| dc.creator (作者) | Chen, Chenyi;Tsai, Shang-Yueh;Tahamata, Valentino Marcel;Chuang, Yi-Hsin;Cheng, Yawei;Fan, Yang-Teng | |
| dc.date (日期) | 2025-10 | |
| dc.date.accessioned | 30-Jan-2026 11:06:58 (UTC+8) | - |
| dc.date.available | 30-Jan-2026 11:06:58 (UTC+8) | - |
| dc.date.issued (上傳時間) | 30-Jan-2026 11:06:58 (UTC+8) | - |
| dc.identifier.uri (URI) | https://ah.lib.nccu.edu.tw/item?item_id=180865 | - |
| dc.description.abstract (摘要) | Brain excitatory–inhibitory (E–I) balance plays a fundamental role in sensory and social processing. Alterations in E–I neurotransmitter systems—commonly indexed by the glutamate and glutamine (Glx)/GABA ratio—have been implicated in various neurodevelopmental conditions, including autism spectrum disorder (ASD). However, how individual differences in E–I balance relate to sensory responsivity and autism-spectrum-related traits in neurotypical populations remains poorly understood. In this study, we evaluated E-I balance across sensory-related brain regions in 92 neurotypical participants to explore its association with sensory responsivity and autistic traits. Our findings revealed that individuals with higher levels of self-reported autistic traits also exhibited stronger associations with sensory responsivity and higher Glx/GABA ratios. In cross-correlation analyses, the Glx/GABA ratio was significantly associated with both autistic traits and sensory responsivity, whereas Glx alone showed fewer associations. Clustering analyses further grouped autistic traits with the Glx/GABA ratio, rather than with the individual metabolite concentrations, suggesting that the ratio may be more behaviorally relevant than either metabolite alone. Moreover, the prefrontal Glx/GABA ratio demonstrated stronger associations with both autistic traits and sensory responsivity compared to other brain regions, a finding further supported by hierarchical moderation and mediation analyses. Overall, these results suggest that individual variability in regional E–I balance may be meaningfully related to sensory and social-affective traits, even within non-clinical populations. These findings may offer insights into the broader neurobiological mechanisms underlying sensory-affective processing across the general population spectrum. | |
| dc.format.extent | 112 bytes | - |
| dc.format.mimetype | text/html | - |
| dc.relation (關聯) | NeuroImage, Vol.320, 121470 | |
| dc.subject (關鍵詞) | Autism spectrum disorders (ASD); Sensory responsivity; Excitation–inhibition balance; Magnetic resonance spectroscopy (MRS); Prefrontal cortex | |
| dc.title (題名) | Decoding the brain＇s excitatory–inhibitory metabolite balance in relation to sensory responsivity and autistic traits | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1016/j.neuroimage.2025.121470. | |
| dc.doi.uri (DOI) | https://doi.org/10.1016/j.neuroimage.2025.121470 | |
