| dc.contributor | 神科所 | |
| dc.creator (作者) | 陳玠文 | |
| dc.creator (作者) | She, Sheng-Chieh;Lin, Chi-Wei;Chen, Chieh-Wen;al, et | |
| dc.date (日期) | 2026-03 | |
| dc.date.accessioned | 7-May-2026 10:32:42 (UTC+8) | - |
| dc.date.available | 7-May-2026 10:32:42 (UTC+8) | - |
| dc.date.issued (上傳時間) | 7-May-2026 10:32:42 (UTC+8) | - |
| dc.identifier.uri (URI) | https://ah.lib.nccu.edu.tw/item?item_id=182356 | - |
| dc.description.abstract (摘要) | Intermittent hypoxia (IH), the key physiological stressor in obstructive sleep apnea, is commonly quantified by respiratory event frequency. However, clinical heterogeneity in hypertension among patients with comparable apnea-hypopnea index (AHI) suggests that episode timing, including the duration and frequency of desaturation-reoxygenation cycles, may exert distinct biological effects even under equal cumulative burden. To test this, male Wistar-Kyoto rats were exposed for 21 days (8 h/day) to IH with either 10-s hypoxia duration at 30 cycles/h (10s-30c) or 5-s hypoxia duration at 60 cycles/h (5s-60c), while room air served as a control. Cardiovascular regulation was evaluated by continuous measurement of mean arterial pressure, heart-rate variability, and baroreflex sensitivity, and broader systemic effects were assessed through sleep-wake architecture, EEG activity, spatial memory, and cortical/hippocampal protein markers. Both IH groups had elevated blood pressure and disrupted autonomic balance compared with controls. The 5s-60c group produced more sustained hypertension, blunted nocturnal dipping, greater baroreflex impairment, and enhanced beta power during sleep, indicating persistent sympathetic drive. By contrast, the 10s-30c group was associated with increased paradoxical sleep, impaired spatial memory, reduced NeuN expression, and stronger upregulation of IBA-1 and NF-κB. These findings demonstrate that equivalent cumulative hypoxic exposure with different temporal structures yields divergent cardiovascular and neurocognitive outcomes. High-frequency, short-duration episodes preferentially promoted cardiovascular dysregulation, whereas longer episodes were linked to neurocognitive vulnerability. Consideration of hypoxic episode duration may improve the mechanistic interpretation of cardiovascular heterogeneity associated with sleep-disordered breathing. | |
| dc.format.extent | 106 bytes | - |
| dc.format.mimetype | text/html | - |
| dc.relation (關聯) | Hypertension Research, Vol.49, pp.1659-1672 | |
| dc.subject (關鍵詞) | Intermittent hypoxia; Blood pressure; Autonomic regulation; Implemental hypertension | |
| dc.title (題名) | Differential cardiovascular and autonomic responses to structurally distinct intermittent hypoxia paradigms in rats | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1038/s41440-026-02588-7 | |
| dc.doi.uri (DOI) | https://doi.org/10.1038/s41440-026-02588-7 | |
