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題名 Predictors of clinical trial participation among older U.S. adults with multimorbidity: a cross-sectional survey 作者 劉叡穎
Schwartz, Janice B.;Liu, Ruey-ying;Boscardin, John;Tarn, Derjung M.貢獻者 社會系 關鍵詞 barriers to participation; clinical trial participation; clinical trials; motivators for participation; representation 日期 2026-05 上傳時間 12-May-2026 10:59:50 (UTC+8) 摘要 Older adults, women, and minorities are under-represented in clinical trials. Our objective was to identify characteristics predicting participation in clinical trials of medications in a diverse sample of older adults; and, secondarily, identify current participation motivators and barriers and trial preferences. A cross-sectional U.S. community convenience sample survey of adults > 65 years with > 3 chronic medical conditions querying attitudes about participation in clinical trials was conducted from March 2023–October 2024 in English and Spanish. Formats were yes/no or three-point Likert scale answers. Multivariable logistic regression identified characteristics with higher likelihood of trial participation. Surveys were from 2176 older adults (White (50.3%), Black/African American (18.5%), Hispanic/Latino (17.7%), Asian (13.5%) aged 73.1 ± 6.1 years (mean, SD), 52% women,one 4.1 ± 1.9 medical conditions; taking 7.4 ± 3.2 medications. Characteristics with higher likelihood of trial participation were higher income (1.36, 0.93–1.99; Odds Ratio, 95% Confidence Interval), educational status (1.88, 1.12–3.0), greater health literacy (2.07, 1.29–3.3), having cancer (1.49, 1.11–1.99) or chronic pain (1.55, 1.17–2.06), Black/African American race (1.44, 1.02–2.02) or Hispanic/Latino race/ethnicity (1.55, 1.11–2.16). Females had lower likelihood of participation (0.66, 1.29–3.32) as did age 75 and above (0.67, 0.50–0.92). Disincentives in women were potential side effects, placeboes, visit travel > 1 h, and video visits. Prior participants and nonparticipants were more likely to consider participation after physician recommendation (92% and 76.4%, respectively). Better care would motivate the highest percentage of all respondents. Education about trials including possible benefits, addressing concerns of women, physician involvement during recruitment and trials with in-person visits may increase representative enrollment. 關聯 Clinical and Translational Science, Vol.19, No.5, e70573 資料類型 article DOI https://doi.org/10.1111/cts.70573 dc.contributor 社會系 dc.creator (作者) 劉叡穎 dc.creator (作者) Schwartz, Janice B.;Liu, Ruey-ying;Boscardin, John;Tarn, Derjung M. dc.date (日期) 2026-05 dc.date.accessioned 12-May-2026 10:59:50 (UTC+8) - dc.date.available 12-May-2026 10:59:50 (UTC+8) - dc.date.issued (上傳時間) 12-May-2026 10:59:50 (UTC+8) - dc.identifier.uri (URI) https://ah.lib.nccu.edu.tw/item?item_id=182485 - dc.description.abstract (摘要) Older adults, women, and minorities are under-represented in clinical trials. Our objective was to identify characteristics predicting participation in clinical trials of medications in a diverse sample of older adults; and, secondarily, identify current participation motivators and barriers and trial preferences. A cross-sectional U.S. community convenience sample survey of adults > 65 years with > 3 chronic medical conditions querying attitudes about participation in clinical trials was conducted from March 2023–October 2024 in English and Spanish. Formats were yes/no or three-point Likert scale answers. Multivariable logistic regression identified characteristics with higher likelihood of trial participation. Surveys were from 2176 older adults (White (50.3%), Black/African American (18.5%), Hispanic/Latino (17.7%), Asian (13.5%) aged 73.1 ± 6.1 years (mean, SD), 52% women,one 4.1 ± 1.9 medical conditions; taking 7.4 ± 3.2 medications. Characteristics with higher likelihood of trial participation were higher income (1.36, 0.93–1.99; Odds Ratio, 95% Confidence Interval), educational status (1.88, 1.12–3.0), greater health literacy (2.07, 1.29–3.3), having cancer (1.49, 1.11–1.99) or chronic pain (1.55, 1.17–2.06), Black/African American race (1.44, 1.02–2.02) or Hispanic/Latino race/ethnicity (1.55, 1.11–2.16). Females had lower likelihood of participation (0.66, 1.29–3.32) as did age 75 and above (0.67, 0.50–0.92). Disincentives in women were potential side effects, placeboes, visit travel > 1 h, and video visits. Prior participants and nonparticipants were more likely to consider participation after physician recommendation (92% and 76.4%, respectively). Better care would motivate the highest percentage of all respondents. Education about trials including possible benefits, addressing concerns of women, physician involvement during recruitment and trials with in-person visits may increase representative enrollment. dc.format.extent 97 bytes - dc.format.mimetype text/html - dc.relation (關聯) Clinical and Translational Science, Vol.19, No.5, e70573 dc.subject (關鍵詞) barriers to participation; clinical trial participation; clinical trials; motivators for participation; representation dc.title (題名) Predictors of clinical trial participation among older U.S. adults with multimorbidity: a cross-sectional survey dc.type (資料類型) article dc.identifier.doi (DOI) 10.1111/cts.70573 dc.doi.uri (DOI) https://doi.org/10.1111/cts.70573
