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題名 Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure involving an elevated stand
作者 Shen, Ying-Ling; Chen, Jin-Chung ;Liao, Ruey-Ming ; 廖瑞銘
貢獻者 國立政治大學心理學系
關鍵詞 Inescapable stress; Dopamine; DOPAC; Medial prefrontal cortex; Nucleus accumbens; HPLC
日期 2011
上傳時間 29-Dec-2008 15:33:42 (UTC+8)
摘要 Acute exposure to an elevated stand has been used as an inescapable mild stressor for rats. The present study examined the effects of this stressor using a place conditioning behavioral test and neurochemical assays of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and nucleus accumbens. The behavioral data showed that a conditioned place preference was formed as an aftereffect of the elevated stand stressor. In a separate experiment, neurochemical assay showed an immediate increase of dopamine in the nucleus accumbens after 30min exposure to the elevated stand stressor. In addition, the DOPAC content in the nucleus accumbens was significantly increased at 30min after this stressor. No significant change in dopamine or DOPAC levels in the medial prefrontal cortex was detected for up to 60min after stressor manipulation. These results suggest that an increase in dopamine activity in the nucleus accumbens is involved in the development of conditioned place preference elicited by the aftereffects of the elevated stand stressor.
關聯 Neuroscience Letters, 504, 156-159
資料類型 article
DOI http://dx.doi.org/10.1016/j.neulet.2011.09.022
dc.contributor 國立政治大學心理學系-
dc.creator (作者) Shen, Ying-Ling; Chen, Jin-Chung ;Liao, Ruey-Ming ; 廖瑞銘en_US
dc.date (日期) 2011en_US
dc.date.accessioned 29-Dec-2008 15:33:42 (UTC+8)-
dc.date.available 29-Dec-2008 15:33:42 (UTC+8)-
dc.date.issued (上傳時間) 29-Dec-2008 15:33:42 (UTC+8)-
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/19804-
dc.description.abstract (摘要) Acute exposure to an elevated stand has been used as an inescapable mild stressor for rats. The present study examined the effects of this stressor using a place conditioning behavioral test and neurochemical assays of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and nucleus accumbens. The behavioral data showed that a conditioned place preference was formed as an aftereffect of the elevated stand stressor. In a separate experiment, neurochemical assay showed an immediate increase of dopamine in the nucleus accumbens after 30min exposure to the elevated stand stressor. In addition, the DOPAC content in the nucleus accumbens was significantly increased at 30min after this stressor. No significant change in dopamine or DOPAC levels in the medial prefrontal cortex was detected for up to 60min after stressor manipulation. These results suggest that an increase in dopamine activity in the nucleus accumbens is involved in the development of conditioned place preference elicited by the aftereffects of the elevated stand stressor.-
dc.format application/en_US
dc.language enen_US
dc.language en-USen_US
dc.language.iso en_US-
dc.relation (關聯) Neuroscience Letters, 504, 156-159en_US
dc.subject (關鍵詞) Inescapable stress; Dopamine; DOPAC; Medial prefrontal cortex; Nucleus accumbens; HPLC-
dc.title (題名) Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure involving an elevated standen_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1016/j.neulet.2011.09.022en_US
dc.doi.uri (DOI) http://dx.doi.org/10.1016/j.neulet.2011.09.022en_US