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題名 Acute Effects of d-Amphetamine on the DRL Schedule Behavior in the Rat: Comparison with Selective Dopamine Receptor Antagonists 作者 Liao, Ruey-Ming
廖瑞銘
Cheng, Ruey-Kuang貢獻者 國立政治大學心理學系 關鍵詞 D1 and D2 receptors; IRT analysis; ketamine; pentylenetetrazole; psychostimulant; raclopride; SCH23390; timing behavior 日期 2005 上傳時間 31-Dec-2008 10:48:03 (UTC+8) 摘要 Amphetamine and it analogs have been shown to affect operant behavior maintained on the differential reinforcement of a low-rate (DRL) schedule. The aim of the present study was to investigate what specific component of the DRL response is affected by d-amphetamine. The acute effects of d-amphetamine on a DRL task were compared with those of the selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively. Pentylenetetrazole and ketamine were also used as two reference drugs for comparison with d-amphetamine as a psychostimulant. Rats were trained to press a lever for water reinforcement on a DRL 10-s schedule. Acute treatment of d-amphetamine (0, 0.5, and 1.0 mg/kg) significantly increased the response rate and decreased the reinforcement in a dose-related fashion. It also caused a horizontal leftward shift in the inter-response time (IRT) distribution at the doses tested. Such a shifting effect was confirmed by a significant decrease in the peak time, while the mean peak rate and burse response remained unaffected. In contrast, both SCH23390 (0, 0.05, and 0.10 mg/kg) and raclopride (0, 0.2, and 0.4 mg/kg) significantly decreased the total, nonreinforced, and burst responses. The de-burst IRT distributions were flattened out as shown by the doserelated decreases in the mean peak rate for both dopamine antagonists, but no dramatic shift in peak time was detected. Interestingly, neither pentylenetetrazole (0, 5, and 10 mg/kg) nor ketamine (0, 1, and 10 mg/kg) disrupted the DRL behavioral performance. It is then conceivable that d-amphetamine at the doses tested affects the temporal regulation of DRL behavior. The effectiveness of d-amphetamine is derived from its drug action as a psychostimulant. Taken together, these data suggest that different behavioral components of DRL task are differentially sensitive to pharmacological manipulation. 關聯 Chinese Journal of Physiology, 48(1), 41-50 資料類型 article dc.contributor 國立政治大學心理學系 - dc.creator (作者) Liao, Ruey-Ming en_US dc.creator (作者) 廖瑞銘 zh_TW dc.creator (作者) Cheng, Ruey-Kuang en_US dc.date (日期) 2005 en_US dc.date.accessioned 31-Dec-2008 10:48:03 (UTC+8) - dc.date.available 31-Dec-2008 10:48:03 (UTC+8) - dc.date.issued (上傳時間) 31-Dec-2008 10:48:03 (UTC+8) - dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/20725 - dc.description.abstract (摘要) Amphetamine and it analogs have been shown to affect operant behavior maintained on the differential reinforcement of a low-rate (DRL) schedule. The aim of the present study was to investigate what specific component of the DRL response is affected by d-amphetamine. The acute effects of d-amphetamine on a DRL task were compared with those of the selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively. Pentylenetetrazole and ketamine were also used as two reference drugs for comparison with d-amphetamine as a psychostimulant. Rats were trained to press a lever for water reinforcement on a DRL 10-s schedule. Acute treatment of d-amphetamine (0, 0.5, and 1.0 mg/kg) significantly increased the response rate and decreased the reinforcement in a dose-related fashion. It also caused a horizontal leftward shift in the inter-response time (IRT) distribution at the doses tested. Such a shifting effect was confirmed by a significant decrease in the peak time, while the mean peak rate and burse response remained unaffected. In contrast, both SCH23390 (0, 0.05, and 0.10 mg/kg) and raclopride (0, 0.2, and 0.4 mg/kg) significantly decreased the total, nonreinforced, and burst responses. The de-burst IRT distributions were flattened out as shown by the doserelated decreases in the mean peak rate for both dopamine antagonists, but no dramatic shift in peak time was detected. Interestingly, neither pentylenetetrazole (0, 5, and 10 mg/kg) nor ketamine (0, 1, and 10 mg/kg) disrupted the DRL behavioral performance. It is then conceivable that d-amphetamine at the doses tested affects the temporal regulation of DRL behavior. The effectiveness of d-amphetamine is derived from its drug action as a psychostimulant. Taken together, these data suggest that different behavioral components of DRL task are differentially sensitive to pharmacological manipulation. - dc.format application/ en_US dc.language en en_US dc.language en-US en_US dc.language.iso en_US - dc.relation (關聯) Chinese Journal of Physiology, 48(1), 41-50 en_US dc.subject (關鍵詞) D1 and D2 receptors; IRT analysis; ketamine; pentylenetetrazole; psychostimulant; raclopride; SCH23390; timing behavior - dc.title (題名) Acute Effects of d-Amphetamine on the DRL Schedule Behavior in the Rat: Comparison with Selective Dopamine Receptor Antagonists en_US dc.type (資料類型) article en
