學術產出-Theses

題名 疾病群聚檢測方法與檢定力比較
Disease Cluster Detection Methods and Power Comparison
作者 王泰期
Wang, Tai-Ci
貢獻者 余清祥
王泰期
Wang, Tai-Ci
關鍵詞 空間群聚
累計型資料
疾病偵測
檢定力
Spatial Cluster
Count Data
Disease Detection
Power
日期 2005
上傳時間 17-Sep-2009 18:49:10 (UTC+8)
摘要 空間群聚分析應用於流行病學已行之有年,但國內這方面的研究仍較缺乏,尤其在找出哪些地區有較高疾病發生率的群聚偵測。本文針對台灣鄉鎮市資料的特性,提出一套合適的群聚檢測方法,這個方法使用兩階段的電腦模擬,實證上更容易使用;這個方法除了可找出最大顯著群聚外,也能夠偵測出多個群聚的分佈。本文使用電腦模擬比較本文的方法與目前使用較為廣泛的方法(包括Kulldorff(1995)的spatial scan statistic和Tango(2005)的flexible scan statistic),以型一誤差、型二誤差及錯誤率三種標準衡量方法的優劣。最後套用台灣癌症死亡率與健保就診次數資料,探討台灣癌症空間群聚與就診情形的變化。
Spatial cluster analyses have applied in epidemiology for many years. In this topic there still are few researches in Taiwan, especially in detecting the areas which have higher disease intensity. In this paper, we proposed a new cluster detection method which is aimed at Taiwan counties’ data. This method which uses two-stage computer simulation procedures is useful in practice. This method can find the most likely cluster. Besides, it can find multiple clusters. We use computer simulations to compare our method with others (Kulldorff’s spatial scan statistic& Tango’s flexible scan statistic). Type-I error, Type-II error and error rate are criterions of measurement. At last, we use Taiwan cancer mortality data and all the people health insurance data to discuss Taiwan cancer spatial clusters and the change of diagnoses.
參考文獻 Alexander, F.E. and Boyle, P. Introduction. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (1)
Alexander, F.E. and Boyle, P. Overview of Results. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (2)
Alexander, F.E. and Boyle, P. Editorial Comments. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (3)
Andrew B. Lawson “Disease cluster detection: A critique and a Bayesian proposal” , Statistics in Medicine, 25: :897–916 (2006).
Besag, J. and Newell, J. “The detection of clusters in rare diseases”, Journal of the Royal Statistical Society, Series A, 154, 143-155 (1991)
Choynowski, M. “Maps based on probabilities”, Journal of the American Statistical Association, 54, 385-388 (1959)
Cressie, N., “Statistics for spatial data (2nd ed.)”, Wiley-Interscience, New York, 1993
CUZICK, J., EDWARDS, R.”Spatial clustering for inhomogeneous populations.”, Journal of the Royal Statistical Society Series B, 52:73-104. (1990)
Gangnon R, Clayton M. “Bayesian detection and modelling of spatial disease clustering”, Biometrics, 56, 922–935 (2000).
Gangnon R, Clayton M. “Cluster modelling for disease rate mapping”, In Spatial Cluster Modelling, Lawson AB, Denison D (eds), Chapter 8. CRC Press: New York, (2002).
Gangnon R. “Impact of prior choice on local Bayes factors for cluster detection” , Statistics in Medicine, 25, 883–895 (2006).
Gardner, M.J. “Review of reported increases of childhood cancer rates in the vicinity of nuclear installations in the UK”, Journal of the Royal Statistical Society, Series A, 152,307-325 (1989).
GRIMSON, R.C. “Disease clusters, exact distributions of maxima, and p-values.” Statistics in Medicine, 12, 1773-1794. (1993)
Hills, M. and Alexander, F., “Statistical methods used in assessing the risk of disease near a source of possible environmental pollution: a review”, Journal of the Royal Statistical Society, Series A, 152, 353-363 (1989).
John Snow, M.D.” On the Mode of Communication of Cholera ” London: John Churchill, New Burlington Street, England, 1855
Knox, E. “Detect of clusters”, in P. Elliot (ed.), Methodology of Enquiries into Disease Clustering, London School of Hygiene and Tropical Medicine, London.(1988).
Kulldorff, M. and Nagarwalla, N. “Spatial disease clusters: detection and inference”, Statistics in Medicine, 14, 799-810 (1995).
Kulldorff, M. “A spatial scan statistic”, Communications in Statistics - Theory and Methods, 26, 1481-1496 (1997).
Kulldorff, M, Tango T, Park PJ. “Power comparisons for disease clustering tests”, Computational Statistics and Data Analysis, 42,665–684 (2003).
Lance A. Waller1, Elizabeth G. Hill and Rose Anne Rudd “The geography of power: Statistical performance of tests clusters and clustering in heterogeneous populations”, Statistics in Medicine, 25: 853–865 (2006).
Luiz Duczmal and David L. Buckeridge ”A work flow spatial scan statistic.” Statistics in Medicine, 25:743–754 (2006).
MANTEL, N., BAILAR, J.C.”A class of permutational and multinomial tests arising in epidemiological research.” Biometrics, 26, 687-700 (1970)
Marshal, R. J. “A review of the statistical analysis of spatial patterns of disease”, Journal of the Royal Statistical Society, Series A, 154, 421-441(1991).
Mary M. Louie and Eric D. Kolaczyk “A multiscale method for disease mapping
in spatial epidemiology”, Statistics in Medicine, 25: 1287–1306 (2006).
Md. Monir Hossain and Andrew B. Lawson “Cluster detection diagnostics for small area health data: With reference to evaluation of local likelihood models” , Statistics in Medicine, 25: :771–786 (2006).
Openshaw, S., Craft, A. W., Charlton, M. G. and Birch, J. M. “Investigation of leukemia clusters by use of a geographical analysis machine”, Lancet, i, 272-273 (1988)
Openshaw S., Turner A., Turton I., Macgill J. ”Testing space-time and more complex hyperspace geographical analysis tools.” (1999)
Online at <http://www.ccg.leeds.ac.uk/smart/hyper.html>
R. Assunc˜ao, M. Costa, A. Tavares and S. Ferreira “Fast detection of arbitrarily shaped disease clusters”, Statistics in Medicine, 25:723–742 (2006).
ROSS, A., DAVIS, S. “Point pattern analysis of the spatial proximity of residences prior to diagnosis of persons with Hodgkin`s disease.” American Journal of Epidemiology, 132, S53-S62. (1990)
Sankoh, O. A., Heiko Becher, “Disease cluster methods in epidemiology and application to data on childhood mortality in rural Burkina Faso”(2002)
online at http://www.hyg.uni-heidelberg.de/sfb544/publikationen.html
Smith, G. H., “Disease cluster detection methods: the impact of choice of shape on the power of statistical tests”, (2002)
online at http://www.cobblestoneconcepts.com/ucgis2summer/smith/SMITH.HTM
Stone, R. A. “Investigations of excess environmental risks around putative sources: statistical problems and a proposed test”, Statistics in Medicine, 7, 649-660 (1988).
Stone, R.A and. Bithell, J.F. (1989) On statistical methods for analyzing the geographical distribution of cancer cases near nuclear installations. Journal of Epidemiology and Community Health, 43, 1, 79-85
Tango, T. “A test for spatial disease clustering adjusted for multiple testing”, Statistics in Medicine, 19, 191-204 (2000)
Tango T, Takahashi K. “A flexibly shaped spatial scan statistic for detecting clusters”, International Journal of Health Geographics, 4, 11 (2005).
Turnbull, B. W., Iwano, E. J., Burnett, W. S., Howe, H. L. and Clark, L. C. “ Monitoring for clusters of disease: application to leukemia incidence in upstate New York”, American Journal of Epidemiology, 132, S136-143 (1990).
Whittemore, A. S., Friend, N., Brown, B. W. and Holly, E. A., “A test to detect clusters of disease”, Biometrika, 74 , 631-635.(1987)
余清祥與陳楓玲, “A Simulation Study of Detecting Clusters: An Application to Taiwan Cancer Mortality”,台灣智慧科技與應用統計學術研討會(2003)
描述 碩士
國立政治大學
統計研究所
933540041
94
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0933540041
資料類型 thesis
dc.contributor.advisor 余清祥zh_TW
dc.contributor.author (Authors) 王泰期zh_TW
dc.contributor.author (Authors) Wang, Tai-Cien_US
dc.creator (作者) 王泰期zh_TW
dc.creator (作者) Wang, Tai-Cien_US
dc.date (日期) 2005en_US
dc.date.accessioned 17-Sep-2009 18:49:10 (UTC+8)-
dc.date.available 17-Sep-2009 18:49:10 (UTC+8)-
dc.date.issued (上傳時間) 17-Sep-2009 18:49:10 (UTC+8)-
dc.identifier (Other Identifiers) G0933540041en_US
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/33923-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 統計研究所zh_TW
dc.description (描述) 933540041zh_TW
dc.description (描述) 94zh_TW
dc.description.abstract (摘要) 空間群聚分析應用於流行病學已行之有年,但國內這方面的研究仍較缺乏,尤其在找出哪些地區有較高疾病發生率的群聚偵測。本文針對台灣鄉鎮市資料的特性,提出一套合適的群聚檢測方法,這個方法使用兩階段的電腦模擬,實證上更容易使用;這個方法除了可找出最大顯著群聚外,也能夠偵測出多個群聚的分佈。本文使用電腦模擬比較本文的方法與目前使用較為廣泛的方法(包括Kulldorff(1995)的spatial scan statistic和Tango(2005)的flexible scan statistic),以型一誤差、型二誤差及錯誤率三種標準衡量方法的優劣。最後套用台灣癌症死亡率與健保就診次數資料,探討台灣癌症空間群聚與就診情形的變化。zh_TW
dc.description.abstract (摘要) Spatial cluster analyses have applied in epidemiology for many years. In this topic there still are few researches in Taiwan, especially in detecting the areas which have higher disease intensity. In this paper, we proposed a new cluster detection method which is aimed at Taiwan counties’ data. This method which uses two-stage computer simulation procedures is useful in practice. This method can find the most likely cluster. Besides, it can find multiple clusters. We use computer simulations to compare our method with others (Kulldorff’s spatial scan statistic& Tango’s flexible scan statistic). Type-I error, Type-II error and error rate are criterions of measurement. At last, we use Taiwan cancer mortality data and all the people health insurance data to discuss Taiwan cancer spatial clusters and the change of diagnoses.en_US
dc.description.tableofcontents 第一章 緒論 1
第一節 研究動機 1
第二節 研究目的 1
第三節 本文編排 2
第二章 文獻回顧 3
第一節 檢定群聚 3
(一)總體性檢定(global test) 3
(二)局部性檢定(local test) 4
(三)焦點性檢定(focus test) 5
第二節 近年相關研究回顧 5
第三節 常見的群聚偵測方法 5
(一)Choynowski Probability Mapping 6
(二)Kulldorff & Nagarwalla Spatial Disease Clusters 6
(三)Tango and Takahashi Flexible Scan Statistics 7
第三章 兩階段的群聚檢測 9
第一節 基本統計模型(群聚分析的常見假設) 9
第二節 單一群聚兩階段群聚檢測方法 10
第三節 多重群聚逐步檢測方法 11
第四節方法特色與圖例說明 11
第四章 群聚檢定方法與模擬檢定結果 13
第一節 模擬設定與檢定表 13
第二節 單一群聚檢測 15
(一)顯著水準對型一誤差及檢定力的影響 15
(二)疾病發生率及人口數對型一誤差及檢定力的影響 16
(三)不同形狀位置群聚對檢定力的影響 18
第三節 多重群聚檢測方法 21
(一)兩群聚型一誤差 22
(二)兩群聚檢定力比較 22
第四節 單一群聚結果修正 26
第五章 方法比較 30
第一節 型一誤差 30
第二節 單一中心圓形群聚檢定力比較 31
第三節 單一中心長形群聚檢定力比較 33
第四節 單一中心Y字形群聚檢定力比較 35
第五節 模擬比較小結 38
第六章 實證應用 39
第一節 83年以及89年台灣癌症死亡人數 39
第二節 台灣門診就診次數變化 43
第三節 實證應用小結 44
第七章 結論與後續研究 46
第一節 結論 46
第二節 後續研究: 47
zh_TW
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dc.language.iso en_US-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0933540041en_US
dc.subject (關鍵詞) 空間群聚zh_TW
dc.subject (關鍵詞) 累計型資料zh_TW
dc.subject (關鍵詞) 疾病偵測zh_TW
dc.subject (關鍵詞) 檢定力zh_TW
dc.subject (關鍵詞) Spatial Clusteren_US
dc.subject (關鍵詞) Count Dataen_US
dc.subject (關鍵詞) Disease Detectionen_US
dc.subject (關鍵詞) Poweren_US
dc.title (題名) 疾病群聚檢測方法與檢定力比較zh_TW
dc.title (題名) Disease Cluster Detection Methods and Power Comparisonen_US
dc.type (資料類型) thesisen
dc.relation.reference (參考文獻) Alexander, F.E. and Boyle, P. Introduction. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (1)zh_TW
dc.relation.reference (參考文獻) Alexander, F.E. and Boyle, P. Overview of Results. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (2)zh_TW
dc.relation.reference (參考文獻) Alexander, F.E. and Boyle, P. Editorial Comments. In Methods for Investigating Localized Clustering of Disease, ed. F.E. Alexander and P. Boyle. Lyon, France: International Agency for Research on Cancer. 1996 (3)zh_TW
dc.relation.reference (參考文獻) Andrew B. Lawson “Disease cluster detection: A critique and a Bayesian proposal” , Statistics in Medicine, 25: :897–916 (2006).zh_TW
dc.relation.reference (參考文獻) Besag, J. and Newell, J. “The detection of clusters in rare diseases”, Journal of the Royal Statistical Society, Series A, 154, 143-155 (1991)zh_TW
dc.relation.reference (參考文獻) Choynowski, M. “Maps based on probabilities”, Journal of the American Statistical Association, 54, 385-388 (1959)zh_TW
dc.relation.reference (參考文獻) Cressie, N., “Statistics for spatial data (2nd ed.)”, Wiley-Interscience, New York, 1993zh_TW
dc.relation.reference (參考文獻) CUZICK, J., EDWARDS, R.”Spatial clustering for inhomogeneous populations.”, Journal of the Royal Statistical Society Series B, 52:73-104. (1990)zh_TW
dc.relation.reference (參考文獻) Gangnon R, Clayton M. “Bayesian detection and modelling of spatial disease clustering”, Biometrics, 56, 922–935 (2000).zh_TW
dc.relation.reference (參考文獻) Gangnon R, Clayton M. “Cluster modelling for disease rate mapping”, In Spatial Cluster Modelling, Lawson AB, Denison D (eds), Chapter 8. CRC Press: New York, (2002).zh_TW
dc.relation.reference (參考文獻) Gangnon R. “Impact of prior choice on local Bayes factors for cluster detection” , Statistics in Medicine, 25, 883–895 (2006).zh_TW
dc.relation.reference (參考文獻) Gardner, M.J. “Review of reported increases of childhood cancer rates in the vicinity of nuclear installations in the UK”, Journal of the Royal Statistical Society, Series A, 152,307-325 (1989).zh_TW
dc.relation.reference (參考文獻) GRIMSON, R.C. “Disease clusters, exact distributions of maxima, and p-values.” Statistics in Medicine, 12, 1773-1794. (1993)zh_TW
dc.relation.reference (參考文獻) Hills, M. and Alexander, F., “Statistical methods used in assessing the risk of disease near a source of possible environmental pollution: a review”, Journal of the Royal Statistical Society, Series A, 152, 353-363 (1989).zh_TW
dc.relation.reference (參考文獻) John Snow, M.D.” On the Mode of Communication of Cholera ” London: John Churchill, New Burlington Street, England, 1855zh_TW
dc.relation.reference (參考文獻) Knox, E. “Detect of clusters”, in P. Elliot (ed.), Methodology of Enquiries into Disease Clustering, London School of Hygiene and Tropical Medicine, London.(1988).zh_TW
dc.relation.reference (參考文獻) Kulldorff, M. and Nagarwalla, N. “Spatial disease clusters: detection and inference”, Statistics in Medicine, 14, 799-810 (1995).zh_TW
dc.relation.reference (參考文獻) Kulldorff, M. “A spatial scan statistic”, Communications in Statistics - Theory and Methods, 26, 1481-1496 (1997).zh_TW
dc.relation.reference (參考文獻) Kulldorff, M, Tango T, Park PJ. “Power comparisons for disease clustering tests”, Computational Statistics and Data Analysis, 42,665–684 (2003).zh_TW
dc.relation.reference (參考文獻) Lance A. Waller1, Elizabeth G. Hill and Rose Anne Rudd “The geography of power: Statistical performance of tests clusters and clustering in heterogeneous populations”, Statistics in Medicine, 25: 853–865 (2006).zh_TW
dc.relation.reference (參考文獻) Luiz Duczmal and David L. Buckeridge ”A work flow spatial scan statistic.” Statistics in Medicine, 25:743–754 (2006).zh_TW
dc.relation.reference (參考文獻) MANTEL, N., BAILAR, J.C.”A class of permutational and multinomial tests arising in epidemiological research.” Biometrics, 26, 687-700 (1970)zh_TW
dc.relation.reference (參考文獻) Marshal, R. J. “A review of the statistical analysis of spatial patterns of disease”, Journal of the Royal Statistical Society, Series A, 154, 421-441(1991).zh_TW
dc.relation.reference (參考文獻) Mary M. Louie and Eric D. Kolaczyk “A multiscale method for disease mappingzh_TW
dc.relation.reference (參考文獻) in spatial epidemiology”, Statistics in Medicine, 25: 1287–1306 (2006).zh_TW
dc.relation.reference (參考文獻) Md. Monir Hossain and Andrew B. Lawson “Cluster detection diagnostics for small area health data: With reference to evaluation of local likelihood models” , Statistics in Medicine, 25: :771–786 (2006).zh_TW
dc.relation.reference (參考文獻) Openshaw, S., Craft, A. W., Charlton, M. G. and Birch, J. M. “Investigation of leukemia clusters by use of a geographical analysis machine”, Lancet, i, 272-273 (1988)zh_TW
dc.relation.reference (參考文獻) Openshaw S., Turner A., Turton I., Macgill J. ”Testing space-time and more complex hyperspace geographical analysis tools.” (1999)zh_TW
dc.relation.reference (參考文獻) Online at <http://www.ccg.leeds.ac.uk/smart/hyper.html>zh_TW
dc.relation.reference (參考文獻) R. Assunc˜ao, M. Costa, A. Tavares and S. Ferreira “Fast detection of arbitrarily shaped disease clusters”, Statistics in Medicine, 25:723–742 (2006).zh_TW
dc.relation.reference (參考文獻) ROSS, A., DAVIS, S. “Point pattern analysis of the spatial proximity of residences prior to diagnosis of persons with Hodgkin`s disease.” American Journal of Epidemiology, 132, S53-S62. (1990)zh_TW
dc.relation.reference (參考文獻) Sankoh, O. A., Heiko Becher, “Disease cluster methods in epidemiology and application to data on childhood mortality in rural Burkina Faso”(2002)zh_TW
dc.relation.reference (參考文獻) online at http://www.hyg.uni-heidelberg.de/sfb544/publikationen.htmlzh_TW
dc.relation.reference (參考文獻) Smith, G. H., “Disease cluster detection methods: the impact of choice of shape on the power of statistical tests”, (2002)zh_TW
dc.relation.reference (參考文獻) online at http://www.cobblestoneconcepts.com/ucgis2summer/smith/SMITH.HTMzh_TW
dc.relation.reference (參考文獻) Stone, R. A. “Investigations of excess environmental risks around putative sources: statistical problems and a proposed test”, Statistics in Medicine, 7, 649-660 (1988).zh_TW
dc.relation.reference (參考文獻) Stone, R.A and. Bithell, J.F. (1989) On statistical methods for analyzing the geographical distribution of cancer cases near nuclear installations. Journal of Epidemiology and Community Health, 43, 1, 79-85zh_TW
dc.relation.reference (參考文獻) Tango, T. “A test for spatial disease clustering adjusted for multiple testing”, Statistics in Medicine, 19, 191-204 (2000)zh_TW
dc.relation.reference (參考文獻) Tango T, Takahashi K. “A flexibly shaped spatial scan statistic for detecting clusters”, International Journal of Health Geographics, 4, 11 (2005).zh_TW
dc.relation.reference (參考文獻) Turnbull, B. W., Iwano, E. J., Burnett, W. S., Howe, H. L. and Clark, L. C. “ Monitoring for clusters of disease: application to leukemia incidence in upstate New York”, American Journal of Epidemiology, 132, S136-143 (1990).zh_TW
dc.relation.reference (參考文獻) Whittemore, A. S., Friend, N., Brown, B. W. and Holly, E. A., “A test to detect clusters of disease”, Biometrika, 74 , 631-635.(1987)zh_TW
dc.relation.reference (參考文獻) 余清祥與陳楓玲, “A Simulation Study of Detecting Clusters: An Application to Taiwan Cancer Mortality”,台灣智慧科技與應用統計學術研討會(2003)zh_TW