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題名 失眠認知行為治療前後生理指標的改變與療效的關係
The Relationships of change in physiological measures and sleep improvement following cognitive behavioral therapy for insomnia
作者 黃冠豪
貢獻者 楊建銘
黃冠豪
關鍵詞 原發性失眠
失眠認知行為治療
中樞神經系統
交感神經系統
副交感神經系統
恆定系統
Primary insomnia
cognitive behavioural therapy for insomnia
central nervous system
sympathetic nervous system
parasympathetic nervous system
homeostatic system
日期 2007
上傳時間 19-Sep-2009 11:56:30 (UTC+8)
摘要 本研究嘗試檢視原發性失眠 (Primary insomnia) 患者在接受完認知行為治療後,其生理激發系統與恆定系統相關生理指標的改變,並探討其主、客觀睡眠改善與生理指標變化之間的關聯,藉以瞭解不同的生理系統在影響原發性失眠患者其主、客觀睡眠改善程度上可能的重要性。本研究透過醫師轉介,共18名原發性失眠患者 (男5人,女13人,平均年齡37.4歲) 接受7週6次的失眠認知行為治療,在接受治療的前後,分別進行一個晚上的多頻道睡眠記錄檢查與主、客觀睡眠評估。再進一步分析高頻率腦波Beta波 (14~35Hz) ,用來反應其中樞神經系統的激發,低頻率腦波Delta波 (0.5~2.5Hz) 則用來反應個案的恆定系統;另外,透過心跳變異率分析得出的參數,包括低頻率 (Low frequency,簡稱LF) 功率與高頻率 (High frequency,簡稱HF) 功率,以LF/HF的比率值測量其交感神經系統的活動,而HF/ (LF+HF) 則是測量副交感神經系統的活動。研究結果顯示個案的失眠問題在主觀睡眠評估指標上有顯著改善,而客觀睡眠評估指標與睡眠結構於入睡時間與入睡後清醒時間有顯著降低,其餘則無顯著改善。而各項生理系統指標,僅後半夜階段二的腦波的Delta波有顯著上升,其餘均無顯著地改善,而LF/HF的下降與失眠嚴重度的下降有顯著地關聯。因此,本研究顯示原發性失眠患者接受認知行為治療前後,其交感神經系統的下降與失眠嚴重度之改善有明顯關聯,推論失眠認知行為治療對於原發性失眠患者的交感神經活動的改善,可能是使其失眠嚴重度改善的關鍵。
The present study evaluated the changes in beta and delta ranges of electroencephalogram (EEG) power and heart rate variability (HRV) after cognitive behavioural therapy for insomnia (CBT-I) to understand the effect of CBT-I on arousal system and homeostatic system. The study also examined the correlations between change of sleep measurement and the physiological index to clarify underlying mechanisms of sleep improved by CBT-I. Eighteen primary insomnia patients (5 males, 13 female, mean age = 37.4) participated in this study. The participants were scheduled to come to the sleep laboratory for polysomnographic (PSG) recording twice, one prior to CBT-I and one following CBT-I. A course of 6-session CBT-I was conducted during a period of seven weeks. Subjects’ changes in subjective ratings of sleep quality and quantity and sleep parameters in PSG were calculated. Spectrum analyses were conducted for their EEG and electrocardiogram (EKG). Beta EEG activity (14~35 Hz) was used to indicate the central nervos system (CNS) arousal level and Delta EEG activity (0.5~2.5 Hz) for the intensity of homeostatic system. Low frequency power (LF) and high frequency power (HF) of the R-R interval were calculated for heart rate variability (HRV). LF/HF ratio was used as a index of sympathetic nervous system activity and the HF/ (LF+HF) ratio as a index of parasympathetic nervous system activity. The results show subjective sleep quality of subjects were significantly improved after CBT-I. PSG shows shortened sleep onset latency and decreased wake time after sleep onset, but not in the other measures. For EEG spectrum and HRV parameters, only Delta EEG activity in stage2 of the second half of the night was significantly improved. In addition, the decrease of LF/HF significantly correlated with the improvement of the insomnia severity index. Thus, the results suggests that sleep improvements by CBT-I may be associated with the reduction of sympathetic arousal.
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描述 碩士
國立政治大學
心理學研究所
92752019
96
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0927520191
資料類型 thesis
dc.contributor.advisor 楊建銘zh_TW
dc.contributor.author (Authors) 黃冠豪zh_TW
dc.creator (作者) 黃冠豪zh_TW
dc.date (日期) 2007en_US
dc.date.accessioned 19-Sep-2009 11:56:30 (UTC+8)-
dc.date.available 19-Sep-2009 11:56:30 (UTC+8)-
dc.date.issued (上傳時間) 19-Sep-2009 11:56:30 (UTC+8)-
dc.identifier (Other Identifiers) G0927520191en_US
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/37083-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 心理學研究所zh_TW
dc.description (描述) 92752019zh_TW
dc.description (描述) 96zh_TW
dc.description.abstract (摘要) 本研究嘗試檢視原發性失眠 (Primary insomnia) 患者在接受完認知行為治療後,其生理激發系統與恆定系統相關生理指標的改變,並探討其主、客觀睡眠改善與生理指標變化之間的關聯,藉以瞭解不同的生理系統在影響原發性失眠患者其主、客觀睡眠改善程度上可能的重要性。本研究透過醫師轉介,共18名原發性失眠患者 (男5人,女13人,平均年齡37.4歲) 接受7週6次的失眠認知行為治療,在接受治療的前後,分別進行一個晚上的多頻道睡眠記錄檢查與主、客觀睡眠評估。再進一步分析高頻率腦波Beta波 (14~35Hz) ,用來反應其中樞神經系統的激發,低頻率腦波Delta波 (0.5~2.5Hz) 則用來反應個案的恆定系統;另外,透過心跳變異率分析得出的參數,包括低頻率 (Low frequency,簡稱LF) 功率與高頻率 (High frequency,簡稱HF) 功率,以LF/HF的比率值測量其交感神經系統的活動,而HF/ (LF+HF) 則是測量副交感神經系統的活動。研究結果顯示個案的失眠問題在主觀睡眠評估指標上有顯著改善,而客觀睡眠評估指標與睡眠結構於入睡時間與入睡後清醒時間有顯著降低,其餘則無顯著改善。而各項生理系統指標,僅後半夜階段二的腦波的Delta波有顯著上升,其餘均無顯著地改善,而LF/HF的下降與失眠嚴重度的下降有顯著地關聯。因此,本研究顯示原發性失眠患者接受認知行為治療前後,其交感神經系統的下降與失眠嚴重度之改善有明顯關聯,推論失眠認知行為治療對於原發性失眠患者的交感神經活動的改善,可能是使其失眠嚴重度改善的關鍵。zh_TW
dc.description.abstract (摘要) The present study evaluated the changes in beta and delta ranges of electroencephalogram (EEG) power and heart rate variability (HRV) after cognitive behavioural therapy for insomnia (CBT-I) to understand the effect of CBT-I on arousal system and homeostatic system. The study also examined the correlations between change of sleep measurement and the physiological index to clarify underlying mechanisms of sleep improved by CBT-I. Eighteen primary insomnia patients (5 males, 13 female, mean age = 37.4) participated in this study. The participants were scheduled to come to the sleep laboratory for polysomnographic (PSG) recording twice, one prior to CBT-I and one following CBT-I. A course of 6-session CBT-I was conducted during a period of seven weeks. Subjects’ changes in subjective ratings of sleep quality and quantity and sleep parameters in PSG were calculated. Spectrum analyses were conducted for their EEG and electrocardiogram (EKG). Beta EEG activity (14~35 Hz) was used to indicate the central nervos system (CNS) arousal level and Delta EEG activity (0.5~2.5 Hz) for the intensity of homeostatic system. Low frequency power (LF) and high frequency power (HF) of the R-R interval were calculated for heart rate variability (HRV). LF/HF ratio was used as a index of sympathetic nervous system activity and the HF/ (LF+HF) ratio as a index of parasympathetic nervous system activity. The results show subjective sleep quality of subjects were significantly improved after CBT-I. PSG shows shortened sleep onset latency and decreased wake time after sleep onset, but not in the other measures. For EEG spectrum and HRV parameters, only Delta EEG activity in stage2 of the second half of the night was significantly improved. In addition, the decrease of LF/HF significantly correlated with the improvement of the insomnia severity index. Thus, the results suggests that sleep improvements by CBT-I may be associated with the reduction of sympathetic arousal.en_US
dc.description.tableofcontents 第一章、文獻探討………………………………………………………………1
第一節、原發性失眠的中樞神經系統過度激發病理…….........3
第二節、原發性失眠的自主神經系統病理…………………………..7
第三節、原發性失眠的恆定機制失調病理…………………………8
第四節、原發性失眠的認知行為治療…………………………………9
第五節、研究目的………………………………………………..……12
第二章、研究方法…………………………………………….……………..15
第一節、受試者………………………………………………….………15
第二節、程序……………………………………………………………16
第三節、研究工具與測量…………………………………………………18
第四節、統計分析…………………………………………………………23
第三章、研究結果…………….…………………………...……………...25
第一節、受試者的基本人口學資料與治療效果…………………………25
第二節、生理系統指標的前後改變………………………………………27
第三節、生理系統指標改變與各項主客觀睡眠評估指標改善間的關聯32
第四章、討論………………………………………………………………………36
第一節、CBT-I的療效…………............................36
第二節、生理指標前後的改變…………………………………………37
第三節、生理系統改變與各項主客觀睡眠評估改善間的關聯………40
第四節、研究限制與未來方向…………………………………..……43
參考文獻………………………………………………………………………..45
附錄
附錄1 失眠嚴重度量表…………………………………………….….53
附錄2 睡前激發程度量表……………………………………………….54
附錄3 匹茲堡睡眠品質量表…………………………………………….55
附錄4 研究個案的人口學資料表………………………………….……57























表目錄
表1. 接受CBT-I前後測的各項療效指標之t檢定摘要表…………........26
表2. 前後測PSG檢查之睡眠結構摘要表…………………….………..….…26
表3. Delta波前後測的t檢定摘要表……….………………………….……28
表4. Beta-1波前後測的t檢定摘要表………………….………………….…29
表5. Beta-2波前後測的t檢定摘要表……...………………………….….29
表6.心跳變異率分析LF/HF、HFn.u.前後測的t檢定摘要表……..……..30
表7.療效有無分組Delta波前後測改變的Wilcoxon signed ranks test
摘要表……..............................................30
表8.療效有無分組Beta-1波前後測改變的Wilcoxon signed ranks test
摘要表……..............................................31
表9.療效有無分組Beta-2波前後測改變的Wilcoxon signed ranks test
摘要表…….............................................31
表10.療效有無分組心跳變異率分析LF/HF、HFn.u.前後測改變的Wilcoxon
signed ranks test摘要表…………………………………………….32
表11.Delta波改變與各療效指標改變之關聯分析摘要表……..........34
表12. Beta-1波改變與各療效指標改變之關聯分析摘要表………..….….34
表13. Beta-2波改變與各療效指標改變之關聯分析摘要表…………………35
表14.心跳變異率分析LF/HF、HFn.u.改變與各療效指標改變之關聯分析摘要
表…..………………………………………………………………………35










圖目錄
圖1心理行為因素透過神經生理調節機制影響睡眠的概念模式…………....3
圖2 Perlis的原發性失眠神經認知模式……………………………………….5
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dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0927520191en_US
dc.subject (關鍵詞) 原發性失眠zh_TW
dc.subject (關鍵詞) 失眠認知行為治療zh_TW
dc.subject (關鍵詞) 中樞神經系統zh_TW
dc.subject (關鍵詞) 交感神經系統zh_TW
dc.subject (關鍵詞) 副交感神經系統zh_TW
dc.subject (關鍵詞) 恆定系統zh_TW
dc.subject (關鍵詞) Primary insomniaen_US
dc.subject (關鍵詞) cognitive behavioural therapy for insomniaen_US
dc.subject (關鍵詞) central nervous systemen_US
dc.subject (關鍵詞) sympathetic nervous systemen_US
dc.subject (關鍵詞) parasympathetic nervous systemen_US
dc.subject (關鍵詞) homeostatic systemen_US
dc.title (題名) 失眠認知行為治療前後生理指標的改變與療效的關係zh_TW
dc.title (題名) The Relationships of change in physiological measures and sleep improvement following cognitive behavioral therapy for insomniaen_US
dc.type (資料類型) thesisen
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