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題名 骨形成蛋白於神經肌肉系統功能之研究 其他題名 Role of Bone Morphogenetic Proteins in the Neuromuscular System 作者 王培育 貢獻者 國立政治大學神經科學研究所
行政院國家科學委員會關鍵詞 基礎醫學;骨形成蛋白;神經肌肉系統 日期 2010 上傳時間 15-Nov-2012 11:24:03 (UTC+8) 摘要 The naturally occurring cell death of developing motor neurons is considered to be guided by the influence of their peripheries (Hamburger, 1934, 1958). Skeletal muscle cells have been implicated as a key source of peripheral-derived survival factors, as the absence of them causes a near total loss of developing motor neurons (Grieshammer et al., 1998). Many neuronal cell types are controlled by a small number of survival factors, with the genetic deletion of a single factor leading to a profound loss of neurons (Lindsay, 1996). Motor neurons, in contrast, appear to be controlled by numerous survival factors. The null mutation of a single, or even multiple, factors only leads to partial loss of motor neurons (Liu and Jaenisch, 2000; Oppenheim et al., 2000; Oppenheim et al., 2001). This may indicate that there are distinct subpopulations of motor neurons (Oppenheim et al., 2000). Equally, it implies that muscle fibers produce more than one regulator of motor neurons, as the consequence of the genetic deletion of them type is more profound than the deletion of any growth factor. 關聯 基礎研究
學術補助
研究期間:9908~ 10007
研究經費:1400仟元資料類型 report dc.contributor 國立政治大學神經科學研究所 en_US dc.contributor 行政院國家科學委員會 en_US dc.creator (作者) 王培育 zh_TW dc.date (日期) 2010 en_US dc.date.accessioned 15-Nov-2012 11:24:03 (UTC+8) - dc.date.available 15-Nov-2012 11:24:03 (UTC+8) - dc.date.issued (上傳時間) 15-Nov-2012 11:24:03 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/55526 - dc.description.abstract (摘要) The naturally occurring cell death of developing motor neurons is considered to be guided by the influence of their peripheries (Hamburger, 1934, 1958). Skeletal muscle cells have been implicated as a key source of peripheral-derived survival factors, as the absence of them causes a near total loss of developing motor neurons (Grieshammer et al., 1998). Many neuronal cell types are controlled by a small number of survival factors, with the genetic deletion of a single factor leading to a profound loss of neurons (Lindsay, 1996). Motor neurons, in contrast, appear to be controlled by numerous survival factors. The null mutation of a single, or even multiple, factors only leads to partial loss of motor neurons (Liu and Jaenisch, 2000; Oppenheim et al., 2000; Oppenheim et al., 2001). This may indicate that there are distinct subpopulations of motor neurons (Oppenheim et al., 2000). Equally, it implies that muscle fibers produce more than one regulator of motor neurons, as the consequence of the genetic deletion of them type is more profound than the deletion of any growth factor. en_US dc.language.iso en_US - dc.relation (關聯) 基礎研究 en_US dc.relation (關聯) 學術補助 en_US dc.relation (關聯) 研究期間:9908~ 10007 en_US dc.relation (關聯) 研究經費:1400仟元 en_US dc.subject (關鍵詞) 基礎醫學;骨形成蛋白;神經肌肉系統 en_US dc.title (題名) 骨形成蛋白於神經肌肉系統功能之研究 zh_TW dc.title.alternative (其他題名) Role of Bone Morphogenetic Proteins in the Neuromuscular System en_US dc.type (資料類型) report en
