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題名 在腎上腺移除模式下觀察微小膠細胞與成體神經新生之間的關係
The relationship between microglia and adult neurogenesis after adrenalectomy
作者 連文瑜
Lien, Wen Yu
貢獻者 賴桂珍
Lai, Guey Jen
連文瑜
Lien, Wen Yu
關鍵詞 微小膠細胞
成體神經新生
神經前驅細胞
腎上腺移除
日期 2012
上傳時間 2-Sep-2013 16:52:30 (UTC+8)
摘要 
參考文獻 Aarum, J., et al. (2003). "Migration and differentiation of neural precursor cells can be directed by microglia." Proceedings of the National Academy of Sciences 100(26): 15983-15988.

Aloisi, F. (2001). "Immune function of microglia." Glia 36(2): 165-179.

Altman, J. and G. D. Das (1965a). "Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats." The Journal of Comparative Neurology 124(3): 319-335.

Altman, J. and G. D. Das (1965b). "Post-Natal Origin of Microneurones in the Rat Brain." Nature 207(5000): 953-956.

Bédard, A. and A. Parent (2004). "Evidence of newly generated neurons in the human olfactory bulb." Developmental Brain Research 151(1–2): 159-168.

Banati, R. B., et al. (1993). "Cytotoxicity of microglia." Glia 7(1): 111-118.

Batchelor, P. E., et al. (1999). "Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor." J Neurosci 19(5): 1708-1716.

Battista, D., et al. (2006). "Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus." European Journal of Neuroscience 23(1): 83-93.

Bower, M., et al. (1997). "Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma." Cancer Chemotherapy and Pharmacology 40(6): 484-488.

Brunson, K. L., et al. (2005). "Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels." Hippocampus 15(4): 491-501.

Butovsky, O., et al. (2006). "Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells." Molecular and Cellular Neuroscience 31(1): 149-160.

Cameron, H. A. and E. Gould (1994). "Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus." Neuroscience 61(2): 203-209.

Cameron, H. A. and R. D. G. McKay (2001). "Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus." The Journal of Comparative Neurology 435(4): 406-417.

Coull, J. A. M., et al. (2005). "BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain." Nature 438(7070): 1017-1021.

Davalos, D., et al. (2005). "ATP mediates rapid microglial response to local brain injury in vivo." Nat Neurosci 8(6): 752-758.

Denny, B. J., et al. (1994). "NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA." Biochemistry 33(31): 9045-9051.

Eadie, B. D., et al. (2005). "Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density." The Journal of Comparative Neurology 486(1): 39-47.

Ehninger, D. and G. Kempermann (2003). "Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex." Cereb Cortex 13(8): 845-851.

Eriksson, P. S., et al. (1998). "Neurogenesis in the adult human hippocampus." Nat Med 4(11): 1313-1317.

Fariñas, I., et al. (2002). "Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia." Brain Research Bulletin 57(6): 809-816.

Farmer, J., et al. (2004). "Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo." Neuroscience 124(1): 71-79.

Frank, M. G., et al. (2006). "Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics." Journal of Neuroscience Methods 151(2): 121-130.

Friedman, H. S., et al. (2000). "Temozolomide and treatment of malignant glioma." Clin Cancer Res 6(7): 2585-2597.

Garthe, A., et al. (2009). "Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies." PLoS One 4(5): e5464.

Gehrmann, J., et al. (1995). "Microglia: Intrinsic immuneffector cell of the brain." Brain Research Reviews 20(3): 269-287.

Gould, E., et al. (1999). "Learning enhances adult neurogenesis in the hippocampal formation." Nat Neurosci 2(3): 260-265.

Graeber, M. B. (2010). "Changing face of microglia." Science 330(6005): 783-788.

Hart, M. G., et al. (2008). "Temozolomide for high grade glioma." Cochrane Database Syst Rev(4): CD007415.

Heese, K., et al. (1998). "NF-κB modulates lipopolysaccharide-induced microglial nerve growth factor expression." Glia 22(4): 401-407.

Hu, Z., et al. (1997). "Adrenalectomy-induced granule cell death is predicated on the disappearance of glucocorticoid receptor immunoreactivity in the rat hippocampal granule cell layer." Brain Research 778(2): 293-301.

Hughes, V. (2012). "Microglia: The constant gardeners." Nature 485(7400): 570-572.

Jacinto, F. V. and M. Esteller (2007). "MGMT hypermethylation: A prognostic foe, a predictive friend." DNA Repair 6(8): 1155-1160.

Kanzawa, T., et al. (2004). "Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells." Cell Death Differ 11(4): 448-457.

Kaplan, M. S. (1983). "Proliferation of subependymal cells in the adult primate CNS: differential uptake of DNA labelled precursors." Journal fur Hirnforschung 24(1): 23-33.

Kempermann, G., et al. (1997). "More hippocampal neurons in adult mice living in an enriched environment." Nature 386(6624): 493-495.

Kettenmann, H., et al. (2011). "Physiology of microglia." Physiol Rev 91(2): 461-553.

Kim, S. U. and J. de Vellis (2005). "Microglia in health and disease." Journal of Neuroscience Research 81(3): 302-313.

Kohman, R. A., et al. (2012). "Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice." Brain, Behavior, and Immunity 26(5): 803-810.

Lawson, L. J., et al. (1992). "Turnover of resident microglia in the normal adult mouse brain." Neuroscience 48(2): 405-415.

Little, A. R., et al. (2006). "Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus." Neurosci Lett 399(1–2): 162-166.

Markus, A., et al. (2002). "Neurotrophic factors and axonal growth." Current Opinion in Neurobiology 12(5): 523-531.

Martínez-Claros, M., et al. (2013). "Adrenalectomy and corticosterone replacement differentially alter CA3 dendritic morphology and new cell survival in the adult rat hippocampus." Journal of Chemical Neuroanatomy 48–49(0): 23-28.

Martinez-Canabal, A., et al. (2013). "Age-dependent effects of hippocampal neurogenesis suppression on spatial learning." Hippocampus 23(1): 66-74.

Mittelbronn, M., et al. (2001). "Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude." Acta Neuropathologica 101(3): 249-255.

Moga, M. M., et al. (2005). "Annexin 7-immunoreactive microglia in the hippocampus of control and adrenalectomized rats." Neurosci Lett 380(1–2): 42-47.

Monje, M. L., et al. (2003). "Inflammatory Blockade Restores Adult Hippocampal Neurogenesis." Science 302(5651): 1760-1765.

Montaron, M. F., et al. (2006). "Lifelong corticosterone level determines age-related decline in neurogenesis and memory." Neurobiology of Aging 27(4): 645-654.

Montaron, M. F., et al. (1999). "Adrenalectomy increases neurogenesis but not PSA-NCAM expression in aged dentate gyrus." European Journal of Neuroscience 11(4): 1479-1485.

Morgan, S. C., et al. (2004). "Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta–Notch signalling cascades." Journal of Neurochemistry 90(1): 89-101.

Newlands, E. S., et al. (1997). "Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials." Cancer treatment reviews 23(1): 35-61.

Niibori, Y., et al. (2012). "Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region." Nat Commun 3: 1253.

Nimmerjahn, A., et al. (2005). "Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo." Science 308(5726): 1314-1318.

Nyakas, C., et al. (1983). "Hippocampal corticosterone receptors and novelty-induced behavioral activity: Effect of kainic acid lesion in the hippocampus." Brain Research 288(1–2): 219-228.

Olah, M., et al. (2009). "Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model." Glia 57(10): 1046-1061.

Peltier, J., et al. (2010). Isolation of Adult Hippocampal Neural Progenitors. Protocols for Adult Stem Cells. I. M. Conboy, D. V. Schaffer, M. H. Barcellos-Hoff and S. Li, Humana Press. 621: 57-63.

Postigo, J. A., et al. (1998). "Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss." Neurosci Lett 241(2–3): 107-110.

Scheff, S. W. and C. W. Cotman (1982). "Chronic glucocorticoid therapy alters axon sprouting in the hippocampal dentate gyrus." Experimental Neurology 76(3): 644-654.

Scheff, S. W., et al. (1986). "Altered regulation of lesion-induced synaptogenesis by adrenalectomy and corticosterone in young adult rats." Experimental Neurology 93(3): 456-470.

Shapira-Lichter, I., et al. (2008). "Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory." Brain, Behavior, and Immunity 22(3): 388-398.

Sierra, A., et al. (2010). "Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis." Cell Stem Cell 7(4): 483-495.

Sloviter, R. S., et al. (1989). "Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy." Science 243(4890): 535-538.

Streit, W. J. (2002). "Microglia as neuroprotective, immunocompetent cells of the CNS." Glia 40(2): 133-139.

Stupp, R., et al. (2001). "Current and future developments in the use of temozolomide for the treatment of brain tumours." The Lancet Oncology 2(9): 552-560.

Tremblay, M. E., et al. (2010). "Microglial interactions with synapses are modulated by visual experience." PLoS Biol 8(11): e1000527.

van Praag, H., et al. (1999). "Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus." Nat Neurosci 2(3): 266-270.

Villano, J. L., et al. (2009). "Temozolomide in malignant gliomas: current use and future targets." Cancer Chemotherapy and Pharmacology 64(4): 647-655.

Widera, D., et al. (2006). "Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling." BMC Neuroscience 7(1): 1-18.

Wong, E. Y. H. and J. Herbert (2005). "Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus." European Journal of Neuroscience 22(4): 785-792.

Wu, J.-P., et al. (2000). "Tumor necrosis factor-alpha modulates the proliferation of neural progenitors in the subventricular/ventricular zone of adult rat brain." Neurosci Lett 292(3): 203-206.

Ziv, Y., et al. (2006). "Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood." Nat Neurosci 9(2): 268-275.
描述 碩士
國立政治大學
神經科學研究所
99754006
101
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0099754006
資料類型 thesis
dc.contributor.advisor 賴桂珍zh_TW
dc.contributor.advisor Lai, Guey Jenen_US
dc.contributor.author (Authors) 連文瑜zh_TW
dc.contributor.author (Authors) Lien, Wen Yuen_US
dc.creator (作者) 連文瑜zh_TW
dc.creator (作者) Lien, Wen Yuen_US
dc.date (日期) 2012en_US
dc.date.accessioned 2-Sep-2013 16:52:30 (UTC+8)-
dc.date.available 2-Sep-2013 16:52:30 (UTC+8)-
dc.date.issued (上傳時間) 2-Sep-2013 16:52:30 (UTC+8)-
dc.identifier (Other Identifiers) G0099754006en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/59445-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 神經科學研究所zh_TW
dc.description (描述) 99754006zh_TW
dc.description (描述) 101zh_TW
dc.description.abstract (摘要) zh_TW
dc.description.tableofcontents 中文摘要 I
英文摘要 II
縮寫表 III
目錄 IV
第一章 緒論 1
一、 成體神經新生 (Adult neurogenesis) …. 1
二、 海馬迴齒狀回 (dentate gyrus, DG) …….. 2
三、 腎上腺移除手術 (Adrenalectomy, ADX) 對於成體神經新生的影響 3
四、 微小膠細胞 (microglia) 在中樞神經系統所扮演之角色 4
五、 Microglia與成體神經新生 5
六、 Microglia與腎上腺移除手術 6
七、 Temozolomide (TMZ) 6
八、 研究動機 7
九、 研究目標 7
第二章 材料方法 9
一、 細胞培養材料 9
二、 化學藥品、抗體 9
三、 實驗動物 11
四、 初代細胞培養 (primary cell culture) 12
1. Coating plate 12
2. Medium、Enzyme cocktail配製 12
3. Percoll solution配製 12
4. Primary microglia 12
5. 神經前驅細胞 (Neural progenitor cells, NPCs) 13
五、 免疫螢光染色 14
1. 組織切片的製備 14
2. 載玻片coating與封片膠的製備 14
3. 組織免疫螢光染色 15
4. 標定物質(IdU, CldU)組織免疫螢光染色 15
5. 細胞免疫螢光染色 16
六、 細胞螢光強度分析 16
1. Neurons的Nestin/Tuj1螢光強度分析 16
2. Neurons的neurite長度分析 17
七、 切片細胞計數分析 17
八、 腎上腺移除手術 (Adrenalectomy) 17
九、 標定物質 (IdU, CldU) 或藥物 (TMZ) 於腦室內持續灌注 18
十、 立體定位手術 (Stereotaxic surgery) 19
第三章 結果 21
一、 腎上腺移除手術後觀察microglia數量變化 21
二、 給藥TMZ後對microglia的影響及造成新生成細胞增加 24
三、 給藥TMZ後觀察對NPCs, immature neurons, mature neurons的影響 28
四、 給藥TMZ後觀察對新生的microglia, NPCs, immature neurons, mature neurons影響 31
五、 ADX後primary DG microglia與NPCs共同培養的觀察 38
六、 NPCs培養在不同的primary DG microglia medium中觀察 43
第四章 討論 47
參考文獻 51		zh_TW
dc.language.iso en_US-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0099754006en_US
dc.subject (關鍵詞) 微小膠細胞zh_TW
dc.subject (關鍵詞) 成體神經新生zh_TW
dc.subject (關鍵詞) 神經前驅細胞zh_TW
dc.subject (關鍵詞) 腎上腺移除zh_TW
dc.title (題名) 在腎上腺移除模式下觀察微小膠細胞與成體神經新生之間的關係zh_TW
dc.title (題名) The relationship between microglia and adult neurogenesis after adrenalectomyen_US
dc.type (資料類型) thesisen
dc.relation.reference (參考文獻) Aarum, J., et al. (2003). "Migration and differentiation of neural precursor cells can be directed by microglia." Proceedings of the National Academy of Sciences 100(26): 15983-15988.

Aloisi, F. (2001). "Immune function of microglia." Glia 36(2): 165-179.

Altman, J. and G. D. Das (1965a). "Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats." The Journal of Comparative Neurology 124(3): 319-335.

Altman, J. and G. D. Das (1965b). "Post-Natal Origin of Microneurones in the Rat Brain." Nature 207(5000): 953-956.

Bédard, A. and A. Parent (2004). "Evidence of newly generated neurons in the human olfactory bulb." Developmental Brain Research 151(1–2): 159-168.

Banati, R. B., et al. (1993). "Cytotoxicity of microglia." Glia 7(1): 111-118.

Batchelor, P. E., et al. (1999). "Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor." J Neurosci 19(5): 1708-1716.

Battista, D., et al. (2006). "Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus." European Journal of Neuroscience 23(1): 83-93.

Bower, M., et al. (1997). "Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma." Cancer Chemotherapy and Pharmacology 40(6): 484-488.

Brunson, K. L., et al. (2005). "Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels." Hippocampus 15(4): 491-501.

Butovsky, O., et al. (2006). "Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells." Molecular and Cellular Neuroscience 31(1): 149-160.

Cameron, H. A. and E. Gould (1994). "Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus." Neuroscience 61(2): 203-209.

Cameron, H. A. and R. D. G. McKay (2001). "Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus." The Journal of Comparative Neurology 435(4): 406-417.

Coull, J. A. M., et al. (2005). "BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain." Nature 438(7070): 1017-1021.

Davalos, D., et al. (2005). "ATP mediates rapid microglial response to local brain injury in vivo." Nat Neurosci 8(6): 752-758.

Denny, B. J., et al. (1994). "NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA." Biochemistry 33(31): 9045-9051.

Eadie, B. D., et al. (2005). "Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density." The Journal of Comparative Neurology 486(1): 39-47.

Ehninger, D. and G. Kempermann (2003). "Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex." Cereb Cortex 13(8): 845-851.

Eriksson, P. S., et al. (1998). "Neurogenesis in the adult human hippocampus." Nat Med 4(11): 1313-1317.

Fariñas, I., et al. (2002). "Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia." Brain Research Bulletin 57(6): 809-816.

Farmer, J., et al. (2004). "Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo." Neuroscience 124(1): 71-79.

Frank, M. G., et al. (2006). "Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics." Journal of Neuroscience Methods 151(2): 121-130.

Friedman, H. S., et al. (2000). "Temozolomide and treatment of malignant glioma." Clin Cancer Res 6(7): 2585-2597.

Garthe, A., et al. (2009). "Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies." PLoS One 4(5): e5464.

Gehrmann, J., et al. (1995). "Microglia: Intrinsic immuneffector cell of the brain." Brain Research Reviews 20(3): 269-287.

Gould, E., et al. (1999). "Learning enhances adult neurogenesis in the hippocampal formation." Nat Neurosci 2(3): 260-265.

Graeber, M. B. (2010). "Changing face of microglia." Science 330(6005): 783-788.

Hart, M. G., et al. (2008). "Temozolomide for high grade glioma." Cochrane Database Syst Rev(4): CD007415.

Heese, K., et al. (1998). "NF-κB modulates lipopolysaccharide-induced microglial nerve growth factor expression." Glia 22(4): 401-407.

Hu, Z., et al. (1997). "Adrenalectomy-induced granule cell death is predicated on the disappearance of glucocorticoid receptor immunoreactivity in the rat hippocampal granule cell layer." Brain Research 778(2): 293-301.

Hughes, V. (2012). "Microglia: The constant gardeners." Nature 485(7400): 570-572.

Jacinto, F. V. and M. Esteller (2007). "MGMT hypermethylation: A prognostic foe, a predictive friend." DNA Repair 6(8): 1155-1160.

Kanzawa, T., et al. (2004). "Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells." Cell Death Differ 11(4): 448-457.

Kaplan, M. S. (1983). "Proliferation of subependymal cells in the adult primate CNS: differential uptake of DNA labelled precursors." Journal fur Hirnforschung 24(1): 23-33.

Kempermann, G., et al. (1997). "More hippocampal neurons in adult mice living in an enriched environment." Nature 386(6624): 493-495.

Kettenmann, H., et al. (2011). "Physiology of microglia." Physiol Rev 91(2): 461-553.

Kim, S. U. and J. de Vellis (2005). "Microglia in health and disease." Journal of Neuroscience Research 81(3): 302-313.

Kohman, R. A., et al. (2012). "Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice." Brain, Behavior, and Immunity 26(5): 803-810.

Lawson, L. J., et al. (1992). "Turnover of resident microglia in the normal adult mouse brain." Neuroscience 48(2): 405-415.

Little, A. R., et al. (2006). "Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus." Neurosci Lett 399(1–2): 162-166.

Markus, A., et al. (2002). "Neurotrophic factors and axonal growth." Current Opinion in Neurobiology 12(5): 523-531.

Martínez-Claros, M., et al. (2013). "Adrenalectomy and corticosterone replacement differentially alter CA3 dendritic morphology and new cell survival in the adult rat hippocampus." Journal of Chemical Neuroanatomy 48–49(0): 23-28.

Martinez-Canabal, A., et al. (2013). "Age-dependent effects of hippocampal neurogenesis suppression on spatial learning." Hippocampus 23(1): 66-74.

Mittelbronn, M., et al. (2001). "Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude." Acta Neuropathologica 101(3): 249-255.

Moga, M. M., et al. (2005). "Annexin 7-immunoreactive microglia in the hippocampus of control and adrenalectomized rats." Neurosci Lett 380(1–2): 42-47.

Monje, M. L., et al. (2003). "Inflammatory Blockade Restores Adult Hippocampal Neurogenesis." Science 302(5651): 1760-1765.

Montaron, M. F., et al. (2006). "Lifelong corticosterone level determines age-related decline in neurogenesis and memory." Neurobiology of Aging 27(4): 645-654.

Montaron, M. F., et al. (1999). "Adrenalectomy increases neurogenesis but not PSA-NCAM expression in aged dentate gyrus." European Journal of Neuroscience 11(4): 1479-1485.

Morgan, S. C., et al. (2004). "Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta–Notch signalling cascades." Journal of Neurochemistry 90(1): 89-101.

Newlands, E. S., et al. (1997). "Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials." Cancer treatment reviews 23(1): 35-61.

Niibori, Y., et al. (2012). "Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region." Nat Commun 3: 1253.

Nimmerjahn, A., et al. (2005). "Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo." Science 308(5726): 1314-1318.

Nyakas, C., et al. (1983). "Hippocampal corticosterone receptors and novelty-induced behavioral activity: Effect of kainic acid lesion in the hippocampus." Brain Research 288(1–2): 219-228.

Olah, M., et al. (2009). "Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model." Glia 57(10): 1046-1061.

Peltier, J., et al. (2010). Isolation of Adult Hippocampal Neural Progenitors. Protocols for Adult Stem Cells. I. M. Conboy, D. V. Schaffer, M. H. Barcellos-Hoff and S. Li, Humana Press. 621: 57-63.

Postigo, J. A., et al. (1998). "Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss." Neurosci Lett 241(2–3): 107-110.

Scheff, S. W. and C. W. Cotman (1982). "Chronic glucocorticoid therapy alters axon sprouting in the hippocampal dentate gyrus." Experimental Neurology 76(3): 644-654.

Scheff, S. W., et al. (1986). "Altered regulation of lesion-induced synaptogenesis by adrenalectomy and corticosterone in young adult rats." Experimental Neurology 93(3): 456-470.

Shapira-Lichter, I., et al. (2008). "Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory." Brain, Behavior, and Immunity 22(3): 388-398.

Sierra, A., et al. (2010). "Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis." Cell Stem Cell 7(4): 483-495.

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