| dc.contributor | 神科所 | en_US |
| dc.creator (作者) | Chen, Hwei-Hsien ; Lin, Yi-Ruu ; Chan, Ming-Huan | en_US |
| dc.creator (作者) | 詹銘煥 | zh_TW |
| dc.date (日期) | 2011.09 | en_US |
| dc.date.accessioned | 9-Apr-2014 17:18:07 (UTC+8) | - |
| dc.date.available | 9-Apr-2014 17:18:07 (UTC+8) | - |
| dc.date.issued (上傳時間) | 9-Apr-2014 17:18:07 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/65232 | - |
| dc.description.abstract (摘要) | Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two major neurodevelopmental stages, brain growth spurt and adolescence, on NMDA receptor-mediated current. Rats were administered with toluene (500 mg/kg, i.p.) or corn oil daily over postnatal days (PN) 4–9 (brain growth spurt) or PN 21–26 (early adolescence). Intracellular electrophysiological recordings employing in CA1 pyramidal neurons in the hippocampal slices were performed during PN 30–38. Toluene exposure during brain growth spurt enhanced NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) by electrical stimulation, but impaired the paired-pulse facilitation and NMDA response by exogenous application of NMDA. Toluene exposure during adolescence resulted in an increase in NMDA receptor-mediated EPSCs and a decrease in exogenous NMDA-induced currents, while lack of any effect on paired-pulse facilitation. These findings suggest that toluene exposure during brain growth spurt and adolescence might result in an increase in synaptic NMDA receptor responsiveness and a decrease in extrasynaptic NMDA receptor responsiveness, while only toluene exposure during brain growth spurt can produce presynaptic modulation in CA1 pyramidal neurons. The functional changes in NMDA receptor-mediated transmission underlying developmental toluene exposure may lead to the neurobehavioral disturbances. | en_US |
| dc.format.extent | 329368 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en_US | - |
| dc.relation (關聯) | Toxicology Letters,205(3), 336-340 | en_US |
| dc.source.uri (資料來源) | http://dx.doi.org/10.1016/j.toxlet.2011.06.026 | en_US |
| dc.subject (關鍵詞) | Solvent; NMDA receptor; Neonatal; Adolescent; EPSCs | en_US |
| dc.title (題名) | Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-d-aspartate receptor-mediated currents in rat hippocampus | en_US |
| dc.type (資料類型) | article | en |
