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題名 Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
作者 YR Lin;HH Chen;YC Lin;CH Ko;MH Chan
詹銘煥
貢獻者 神科所
日期 2009.1
上傳時間 9-Apr-2014 17:43:43 (UTC+8)
摘要 The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), and metabotropic glutamate 5 receptor (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), as well as inflammatory mediators such as substance P and prostaglandin E2 (PGE2) in mice. The actions of honokiol and magnolol on glutamate-induced c-Fos expression in the spinal cord dorsal horn were also examined. Our data showed that honokiol and magnolol blocked glutamate-, substance P- and PGE2-induced inflammatory pain with similar potency and efficacy. Consistently, honokiol and magnolol significantly decreased glutamate-induced c-Fos protein expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn. However, honokiol was more selective than magnolol for inhibition of NMDA-induced licking behavioral and thermal hyperalgesia. In contrast, magnolol was more potent to block CHPG-mediated thermal hyperalgesia. These results demonstrate that honokiol and magnolol effectively decreased the inflammatory pain. Furthermore, their different potency on inhibition of nociception provoked by NMDA receptor and mGluR5 activation should be considered.
關聯 Journal of Biomedical Science,16(1), 94
資料類型 article
DOI http://dx.doi.org/10.1186/1423-0127-16-94
dc.contributor 神科所en_US
dc.creator (作者) YR Lin;HH Chen;YC Lin;CH Ko;MH Chanen_US
dc.creator (作者) 詹銘煥zh_TW
dc.date (日期) 2009.1en_US
dc.date.accessioned 9-Apr-2014 17:43:43 (UTC+8)-
dc.date.available 9-Apr-2014 17:43:43 (UTC+8)-
dc.date.issued (上傳時間) 9-Apr-2014 17:43:43 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/65234-
dc.description.abstract (摘要) The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), and metabotropic glutamate 5 receptor (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), as well as inflammatory mediators such as substance P and prostaglandin E2 (PGE2) in mice. The actions of honokiol and magnolol on glutamate-induced c-Fos expression in the spinal cord dorsal horn were also examined. Our data showed that honokiol and magnolol blocked glutamate-, substance P- and PGE2-induced inflammatory pain with similar potency and efficacy. Consistently, honokiol and magnolol significantly decreased glutamate-induced c-Fos protein expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn. However, honokiol was more selective than magnolol for inhibition of NMDA-induced licking behavioral and thermal hyperalgesia. In contrast, magnolol was more potent to block CHPG-mediated thermal hyperalgesia. These results demonstrate that honokiol and magnolol effectively decreased the inflammatory pain. Furthermore, their different potency on inhibition of nociception provoked by NMDA receptor and mGluR5 activation should be considered.en_US
dc.format.extent 594929 bytes-
dc.format.mimetype application/pdf-
dc.language.iso en_US-
dc.relation (關聯) Journal of Biomedical Science,16(1), 94en_US
dc.title (題名) Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory painen_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1186/1423-0127-16-94en_US
dc.doi.uri (DOI) http://dx.doi.org/10.1186/1423-0127-16-94 en_US