1. NCCU Academic Hub
  2. 學術產出
  3. College of Science
  4. Periodical Articles
  5. Item

學術產出-Periodical Articles

Article View/Open

Publication Export

Google ScholarTM

政大圖書館

Citation Infomation

題名 Integrin αv and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats
作者 趙知章
Chao,Chih Chang ; Ma,YL; Chu,KY; Lee,EH
貢獻者 神科所
關鍵詞 Glial cell line-derived neurotrophic factor; Substantia nigra; Integrin; NCAM; Mesencephalic culture
日期 2003.01
上傳時間 23-Sep-2014 12:25:48 (UTC+8)
摘要 Glial cell line-derived neurotrophic factor (GDNF) is a specific neurotrophic factor for midbrain dopamine (DA) neurons, but the mechanism underlying the neurotrophic action of GDNF is not well known. The cell adhesion molecules integrin and Neural cell adhesion molecule (NCAM) play important roles in neurite outgrowth and fasciculation. In the present study, we found that subchronic GDNF administration to the pars compacta of substantia nigra in rats increased the expression of integrin alphav and NCAM. Immunostaining results demonstrated the wide distribution of integrin alphav and NCAM in all mesencephalic neurons. The results also demonstrated the co-expression of TH with integrin alphav and NCAM in the same neurons of mesencephalic culture. Further, GDNF significantly increased integrin alphav expression in single TH-positive neurons. Function-blocking anti-integrin alphav and anti-NCAM antibodies antagonized the effects of GDNF on DA neuron survival, outgrowth, DA turnover, and locomotor activity in rats. These results demonstrate that integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival and outgrowth during development and on DA turnover and motor function during adulthood.
關聯 Neurobiology of Aging,24(1),105-116
資料類型 article
DOI http://dx.doi.org/10.1016/S0197-4580(02)00047-7
dc.contributor 神科所en_US
dc.creator (作者) 趙知章zh_TW
dc.creator (作者) Chao,Chih Chang ; Ma,YL; Chu,KY; Lee,EHen_US
dc.date (日期) 2003.01en_US
dc.date.accessioned 23-Sep-2014 12:25:48 (UTC+8)-
dc.date.available 23-Sep-2014 12:25:48 (UTC+8)-
dc.date.issued (上傳時間) 23-Sep-2014 12:25:48 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/70090-
dc.description.abstract (摘要) Glial cell line-derived neurotrophic factor (GDNF) is a specific neurotrophic factor for midbrain dopamine (DA) neurons, but the mechanism underlying the neurotrophic action of GDNF is not well known. The cell adhesion molecules integrin and Neural cell adhesion molecule (NCAM) play important roles in neurite outgrowth and fasciculation. In the present study, we found that subchronic GDNF administration to the pars compacta of substantia nigra in rats increased the expression of integrin alphav and NCAM. Immunostaining results demonstrated the wide distribution of integrin alphav and NCAM in all mesencephalic neurons. The results also demonstrated the co-expression of TH with integrin alphav and NCAM in the same neurons of mesencephalic culture. Further, GDNF significantly increased integrin alphav expression in single TH-positive neurons. Function-blocking anti-integrin alphav and anti-NCAM antibodies antagonized the effects of GDNF on DA neuron survival, outgrowth, DA turnover, and locomotor activity in rats. These results demonstrate that integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival and outgrowth during development and on DA turnover and motor function during adulthood.en_US
dc.format.extent 428029 bytes-
dc.format.mimetype application/pdf-
dc.language.iso en_US-
dc.relation (關聯) Neurobiology of Aging,24(1),105-116en_US
dc.subject (關鍵詞) Glial cell line-derived neurotrophic factor; Substantia nigra; Integrin; NCAM; Mesencephalic cultureen_US
dc.title (題名) Integrin αv and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in ratsen_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1016/S0197-4580(02)00047-7-
dc.doi.uri (DOI) http://dx.doi.org/10.1016/S0197-4580(02)00047-7-