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| Title | Differential expression of RARbeta isoforms in the mouse striatum during development: a gradient of RARbeta2 expression along the rostrocaudal axis. |
| Creator | 廖文霖 Liao, Wen-Lin ;Tsai,HC;Wu,CY;Liu,FC |
| Contributor | 神科所 |
| Key Words | basal ganglia; lateral ganglionic eminence; nucleus accumbens; retinoic acid; telencephalon |
| Date | 2005.01 |
| Date Issued | 23-Sep-2014 12:27:27 (UTC+8) |
| Summary | The retinoic acid receptor RARbeta is highly expressed in the striatum of the ventral telencephalon. We studied the expression pattern of different RARbeta isoforms in the developing mouse striatum by in situ hybridization. We found a differential ontogeny of RARbeta2 and RARbeta1/3 in embryonic day (E) 13.5 lateral ganglionic eminence (striatal primordium). RARbeta2 mRNA was detected primarily in the rostral and ventromedial domains, whereas RARbeta1/3 mRNAs were enriched in the caudal and dorsolateral domains. Notably, by E16.5, a prominent decreasing gradient of RARbeta2 mRNA was present in the developing striatum along the rostrocaudal axis, i.e., RARbeta2 was expressed at higher levels in the rostral than the caudal striatum. No such gradient was found for RARbeta1/3 and RARbeta3 mRNAs. The rostrocaudal RARbeta2 gradient gradually disappeared postnatally and was absent in the adult striatum. The differential expression pattern of RARbeta isoforms in the developing striatum may provide an anatomical basis for differential gene regulation by RARbeta signaling. |
| Relation | Developmental Dynamics,233(2),584-594. |
| Type | article |
| dc.contributor | 神科所 | en_US |
| dc.creator (作者) | 廖文霖 | zh_TW |
| dc.creator (作者) | Liao, Wen-Lin ;Tsai,HC;Wu,CY;Liu,FC | en_US |
| dc.date (日期) | 2005.01 | en_US |
| dc.date.accessioned | 23-Sep-2014 12:27:27 (UTC+8) | - |
| dc.date.available | 23-Sep-2014 12:27:27 (UTC+8) | - |
| dc.date.issued (上傳時間) | 23-Sep-2014 12:27:27 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/70098 | - |
| dc.description.abstract (摘要) | The retinoic acid receptor RARbeta is highly expressed in the striatum of the ventral telencephalon. We studied the expression pattern of different RARbeta isoforms in the developing mouse striatum by in situ hybridization. We found a differential ontogeny of RARbeta2 and RARbeta1/3 in embryonic day (E) 13.5 lateral ganglionic eminence (striatal primordium). RARbeta2 mRNA was detected primarily in the rostral and ventromedial domains, whereas RARbeta1/3 mRNAs were enriched in the caudal and dorsolateral domains. Notably, by E16.5, a prominent decreasing gradient of RARbeta2 mRNA was present in the developing striatum along the rostrocaudal axis, i.e., RARbeta2 was expressed at higher levels in the rostral than the caudal striatum. No such gradient was found for RARbeta1/3 and RARbeta3 mRNAs. The rostrocaudal RARbeta2 gradient gradually disappeared postnatally and was absent in the adult striatum. The differential expression pattern of RARbeta isoforms in the developing striatum may provide an anatomical basis for differential gene regulation by RARbeta signaling. | en_US |
| dc.format.extent | 1037718 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en_US | - |
| dc.relation (關聯) | Developmental Dynamics,233(2),584-594. | en_US |
| dc.subject (關鍵詞) | basal ganglia; lateral ganglionic eminence; nucleus accumbens; retinoic acid; telencephalon | en_US |
| dc.title (題名) | Differential expression of RARbeta isoforms in the mouse striatum during development: a gradient of RARbeta2 expression along the rostrocaudal axis. | en_US |
| dc.type (資料類型) | article | en |