| dc.contributor | 法科所 | - |
| dc.creator (作者) | Li, Mingchieh; Wu, H.-P.; Yang, C.-Y.; Chen, P.-C.; Lambert, G.H.; Leon, Guo Y. | - |
| dc.creator (作者) | 李銘杰 | - |
| dc.date (日期) | 2015-02 | - |
| dc.date.accessioned | 25-Mar-2015 10:15:56 (UTC+8) | - |
| dc.date.available | 25-Mar-2015 10:15:56 (UTC+8) | - |
| dc.date.issued (上傳時間) | 25-Mar-2015 10:15:56 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/74028 | - |
| dc.description.abstract (摘要) | Abstract Introduction In 1979, approximately 2000 people in central Taiwan were exposed to polychlorinated biphenyls and dibenzofurans (PCBs/PCDFs) due to ingestion of contaminated rice oil. The children born to mothers exposed to PCBs/PCDFs were called Yucheng children. We conducted a follow-up study to examine the association between gestational PCBs/PCDFS exposure and auditory function in Yucheng children`s early adulthood. Methods In 1985 and early 1992, Yucheng children and their age, gender, socio-economic matched unexposed referent children were recruited for physical examination and long-term follow-ups. In 2007, Yucheng children and referent children were invited to participate in a health examination, including assessment of pure-tone air-conduction thresholds and distortion product otoacoustic emissions (DPOAEs) test. Gestational exposure to PCBs/PCDFs in Yucheng children were estimated by back-extrapolation of their mother`s serum concentration to the time of childbirth. Results A total of 86 Yucheng children (51.2% males) and 97 referent children (50.5% males) were included for analysis. No difference was found in demographic characteristics between two groups. Among the Yucheng children, 53 had estimated PCBs/PCDFs concentrations. We found that Yucheng children were at higher risk of having elevated hearing threshold at low frequencies in the right ear. Estimated maternal concentrations of 2,3,4,7,8-pnCDF at the time of birth were associated with increased hearing thresholds and decreased DPOAEs amplitudes at low frequencies in the right ear. Conclusion Gestational exposure to PCBs/PCDFs caused adverse asymmetrical hearing effects detectable even in early adulthood. | - |
| dc.format.extent | 339206 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Environmental Research,137,65-71 | - |
| dc.subject (關鍵詞) | Polychlorinated dibenzofurans; Polychlorinated biphenyls; PCDFs; PCBs; Yucheng; Hearing loss; Prenatal; Gestational | - |
| dc.title (題名) | Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1016/j.envres.2014.12.002 | en_US |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1016/j.envres.2014.12.002 | en_US |
