| dc.contributor | 心理系 | - |
| dc.creator (作者) | Pan, Chun-Hung | - |
| dc.creator (作者) | 潘俊宏 | zh_TW |
| dc.creator (作者) | Huang, M.-C. | en_US |
| dc.creator (作者) | Chen, C.-C. | en_US |
| dc.date (日期) | 2014-10 | - |
| dc.date.accessioned | 2-Jun-2015 17:03:33 (UTC+8) | - |
| dc.date.available | 2-Jun-2015 17:03:33 (UTC+8) | - |
| dc.date.issued (上傳時間) | 2-Jun-2015 17:03:33 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/75518 | - |
| dc.description.abstract (摘要) | Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p < 0.001). A significant correlation was found between the highest CIWA-Ar-C scores and serum 8-OHdG levels (β = 0.43, p = 0.001) in the non-DTs group, but not in the DTs group (β = 0.34, p = 0.19). An area under receiver operating characteristic curve of 0.83 suggests that 8-OHdG levels potentially differentiate patients with DTs from those without DTs. After dividing the patients into quartiles by 8-OHdG level, we found that compared to the patients in the third and fourth quartiles, the patients in the highest quartile had an odds ratio of 24.1 (p < 0.001) to have DTs, while those in the second highest quartile had an odds ratio of 3.5 (p = 0.19). Serum 8-OHdG levels did not significantly change after 1 week of detoxification in either group. Conclusions: Alcohol-dependent patients with DTs have higher serum 8-OHdG levels than those without DTs, suggesting that higher oxidative stress carries a greater risk of the occurrence of DTs. | - |
| dc.format.extent | 193680 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Alcoholism: Clinical and Experimental Research, 38(10), 2523-2528 | - |
| dc.subject (關鍵詞) | 8-Hydroxy-2-Deoxyguanosine; Alcohol Dependence; Alcohol Withdrawal; Delirium Tremens; Oxidative Stress | - |
| dc.title (題名) | Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1111/acer.12539 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1111/acer.12539 | - |
