| dc.contributor | 神經科學研究所;心腦學研究中心 | - |
| dc.creator (作者) | Chan, Ming-Huan;Tsai, Yi-Ling;Lee, Mei-Yi;Stoker, Astrid;Markou, K. Athina;Chen, Hwei-Hsien | - |
| dc.creator (作者) | 詹銘煥;蔡依玲 | - |
| dc.date (日期) | 2015-06 | - |
| dc.date.accessioned | 5-Aug-2015 14:11:45 (UTC+8) | - |
| dc.date.available | 5-Aug-2015 14:11:45 (UTC+8) | - |
| dc.date.issued (上傳時間) | 5-Aug-2015 14:11:45 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/77409 | - |
| dc.description.abstract (摘要) | Rationale Toluene, a widely abused solvent with demonstrated addictive potential in humans, hasbeen reported to negatively modulate N-methyl-D-aspartate receptors (NMDARs) and alter glutamatergicneurotransmission. The group II metabotropic glutamate receptor (mGluR) agonist LY379268 has beenshown to regulate glutamate release transmission and NMDAR function and block toluene-induced locomotorhyperactivity. However, remaining unknown is whether group II mGluRs are involved in the toluene-induced reward-facilitating effect and other behavioral manifestations. Objectives The present study evaluated the effects of LY379268 on toluene-induced reward enhancement, motor incoordination, recognition memory impairment, and social interaction deficits. Results Our data demonstrated that LY379268 significantly reversed the toluene-induced lowering of intracranial selfstimulation (ICSS) thresholds and impairments in novel objectrecognition, rotarod performance, and social interaction with different potencies. Conclusions These results indicate a negative modulatory role of group II mGluRs in acute toluene-induced reward-facilitating and behavioral effects and suggest that group II mGluR agonists may have therapeutic potential for toluene addiction and the prevention of toluene intoxication caused by occupational or intentional exposure. | - |
| dc.format.extent | 935049 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Psychopharmacology | - |
| dc.subject (關鍵詞) | Toluene;mGluR2/3;Motor coordination;Object recognition;Social interaction;Intracranial self-stimulation | - |
| dc.title (題名) | The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1007/s00213-015-3973-3 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1007/s00213-015-3973-3 | - |
