| dc.contributor | 心理學系 | - |
| dc.creator (作者) | Lin, Chih-Lin | - |
| dc.creator (作者) | 林志陵 | zh_TW |
| dc.creator (作者) | Tseng, Tai-Chung | en_US |
| dc.creator (作者) | Su, Tung-Hung | en_US |
| dc.creator (作者) | Liu, Chun-Jen | en_US |
| dc.creator (作者) | Chen, Pei-Jer | en_US |
| dc.creator (作者) | Lai, Ming-Yang | en_US |
| dc.creator (作者) | Chen, Ding-Shinn | en_US |
| dc.creator (作者) | Kao, Jia-Horng | en_US |
| dc.date (日期) | 2012-06 | - |
| dc.date.accessioned | 5-Aug-2015 14:36:54 (UTC+8) | - |
| dc.date.available | 5-Aug-2015 14:36:54 (UTC+8) | - |
| dc.date.issued (上傳時間) | 5-Aug-2015 14:36:54 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/77425 | - |
| dc.description.abstract (摘要) | Purpose:A significant portion of HBeAg-negative chronic hepatitis B patients have persistently normal serum alanine aminotransferase levels (PNALT). We thus investigated host genetic variants and virological features in HBeAg-negative hepatitis B carriers.Methods:Baseline clinical and virological features of 133 HBeAg-negative hepatitis B carriers (77 with PNALT and 56 with chronic hepatitis activity) with follow-up for more than 5 years were investigated. Three single nucleotide polymorphisms (SNPs) located within or around human leukocyte antigen (HLA)-DPA1, HLA-DPB1, and interleukin (IL) 28B loci were genotyped.Results:The genotype frequencies of these SNPs were comparable between hepatitis B carriers with PNALT and those with chronic hepatitis. Compared with hepatitis B carriers with PNALT, those with chronic hepatitis had significantly higher baseline serum HBV-DNA levels (4.96 vs. 4.04 log10 IU/ml, P = 0.001). Baseline serum HBV-DNA level > 2000 IU/ml (OR, 8.42; 95% CI, 2.74–25.90, P < 0.001) were the only independent factor associated with chronic hepatitis activity. Changes of serum HBV-DNA in 30 hepatitis B carriers with PNALT had showed a significant reduction of viral load from baseline to last visit (mean difference of paired HBV-DNA levels: −0.78 log10 IU/ml, 95% CI: −1.57 to −0.013, P = 0.047). In contrast, no significant reduction of viral load was found in 28 patients with chronic hepatitis.Conclusions:The results indicate that lower baseline serum HBV-DNA level and viral load reduction over time are associated with long-term biochemical remission in HBeAg-negative hepatitis B carriers. | - |
| dc.format.extent | 200497 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Hepatology International,6,(3),598-605 | - |
| dc.subject (關鍵詞) | HBeAg-negative carrier;Hepatitis B virus;HBV-DNA;Alanine aminotransferase;Host genetic variants | - |
| dc.title (題名) | Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1007/s12072-011-9297-4 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1007/s12072-011-9297-4 | - |
