| dc.contributor | 統計學系 | |
| dc.creator (作者) | Lin, Hui-Wen | |
| dc.creator (作者) | 林惠文 | zh_TW |
| dc.date (日期) | 2008-03 | |
| dc.date.accessioned | 5-Nov-2015 18:28:30 (UTC+8) | - |
| dc.date.available | 5-Nov-2015 18:28:30 (UTC+8) | - |
| dc.date.issued (上傳時間) | 5-Nov-2015 18:28:30 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/79348 | - |
| dc.description.abstract (摘要) | We consider genetic association analysis that combines data from case-parent trios/sibships and unrelated controls. A general and simple methodology is proposed, using a weighted least-squares approach to combine separate information from the case-parent/case-sibling analysis and the case-unrelated control analysis. The new proposal improves over the existing methods in that it requires no assumptions and estimation on the mating-type distribution. Simulation results show that the new method competes well with the likelihood-based method when the latter is applicable, and achieves substantial power gains over separate analyses in general. Therefore, the proposed combined association analysis can enjoy wide applications, including the multiallele/locus, haplotype, and genome-wide association studies | |
| dc.format.extent | 189528 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Genetic Epidemiology,32(6),520-527 | |
| dc.subject (關鍵詞) | case-control studies;combined association analysis;family-based association analysis;population-based association analysis | |
| dc.title (題名) | Simple association analysis combining data from trios/sibships and unrelated controls | |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1002/gepi.20325 | |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1002/gepi.20325 | |
