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題名 Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice
作者 Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu
江振東
貢獻者 統計系
日期 2015-10
上傳時間 25-十一月-2015 16:35:57 (UTC+8)
摘要 In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients.
關聯 PLoS One, 10(10), e0139722
資料類型 article
DOI http://dx.doi.org/10.1371/journal.pone.0139722
dc.contributor 統計系-
dc.creator (作者) Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu-
dc.creator (作者) 江振東-
dc.date (日期) 2015-10-
dc.date.accessioned 25-十一月-2015 16:35:57 (UTC+8)-
dc.date.available 25-十一月-2015 16:35:57 (UTC+8)-
dc.date.issued (上傳時間) 25-十一月-2015 16:35:57 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/79419-
dc.description.abstract (摘要) In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients.-
dc.format.extent 1169960 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) PLoS One, 10(10), e0139722-
dc.title (題名) Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice-
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1371/journal.pone.0139722-
dc.doi.uri (DOI) http://dx.doi.org/10.1371/journal.pone.0139722-