| dc.contributor | 統計系 | - |
| dc.creator (作者) | Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu | - |
| dc.creator (作者) | 江振東 | - |
| dc.date (日期) | 2015-10 | - |
| dc.date.accessioned | 25-Nov-2015 16:35:57 (UTC+8) | - |
| dc.date.available | 25-Nov-2015 16:35:57 (UTC+8) | - |
| dc.date.issued (上傳時間) | 25-Nov-2015 16:35:57 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/79419 | - |
| dc.description.abstract (摘要) | In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients. | - |
| dc.format.extent | 1169960 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | PLoS One, 10(10), e0139722 | - |
| dc.title (題名) | Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1371/journal.pone.0139722 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1371/journal.pone.0139722 | - |
