| dc.contributor | 應物所 | - |
| dc.creator (作者) | Tsai, Shang-Yueh;Hsu, Yi-Cheng;Chu, Ying-Hua;Kuo, Wen-Jui;Lin, Fa-Hsuan | - |
| dc.creator (作者) | 蔡尚岳 | - |
| dc.date (日期) | 2015-10 | - |
| dc.date.accessioned | 25-Nov-2015 16:36:41 (UTC+8) | - |
| dc.date.available | 25-Nov-2015 16:36:41 (UTC+8) | - |
| dc.date.issued (上傳時間) | 25-Nov-2015 16:36:41 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/79423 | - |
| dc.description.abstract (摘要) | One major challenge of MRSI is the poor signal-to-noise ratio (SNR), which can be improved by using a surface coil array. Here we propose to exploit the spatial sensitivity of different channels of a coil array to enforce the k-space data consistency (DC) in order to suppress noise and consequently to improve MRSI SNR. MRSI data were collected using a proton echo planar spectroscopic imaging (PEPSI) sequence at 3 T using a 32-channel coil array and were averaged with one, two and eight measurements (avg-1, avg-2 and avg-8). The DC constraint was applied using a regularization parameter λ of 1, 2, 3, 5 or 10. Metabolite concentrations were quantified using LCModel. Our results show that the suppression of noise by applying the DC constraint to PEPSI reconstruction yields up to 32% and 27% SNR gain for avg-1 and avg-2 data with λ = 5, respectively. According to the reported Cramer–Rao lower bounds, the improvement in metabolic fitting was significant (p < 0.01) when the DC constraint was applied with λ ≥ 2. Using the DC constraint with λ = 3 or 5 can minimize both root-mean-square errors and spatial variation for all subjects using the avg-8 data set as reference values. Our results suggest that MRSI reconstructed with a DC constraint can save around 70% of scanning time to obtain images and spectra with similar SNRs using λ = 5. | - |
| dc.format.extent | 2629793 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | NMR in Biomedicine, 刊登於網路, 1-10 | - |
| dc.subject (關鍵詞) | proton echo planar spectroscopy imaging; data consistency; SNR; regularization | - |
| dc.title (題名) | Combining parallel detection of proton echo planar spectroscopic imaging (PEPSI) measurements with a data-consistency constraint improves SNR | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1002/nbm.3425 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1002/nbm.3425 | - |
