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題名 Investigation of Readout RF Pulse Impact on the Chemical Exchange Saturation Transfer Spectrum
作者 Huang, Sheng-Min;Jan, Meei-Ling;Liang, Hsin-Chin;Chang, Chia-Hao;Wu, Yi-Chun;Tsai, Shang-Yueh;Wang, Fu-Nien
蔡尚岳
貢獻者 應物所
日期 2015-10
上傳時間 25-Nov-2015 16:37:06 (UTC+8)
摘要 Chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) is capable of both microenvironment and molecular imaging. The optimization of scanning parameters is important since the CEST effect is sensitive to factors such as saturation power and field homogeneity. The aim of this study was to determine if the CEST effect would be altered by changing the length of readout RF pulses. Both theoretical computer simulation and phantom experiments were performed to examine the influence of readout RF pulses. Our results showed that the length of readout RF pulses has unremarkable impact on the Z-spectrum and CEST effect in both computer simulation and phantom experiment. Moreover, we demonstrated that multiple refocusing RF pulses used in rapid acquisition with relaxation enhancement (RARE) sequence induced no obvious saturation transfer contrast. Therefore, readout RF pulse has negligible effect on CEST Z-spectrum and the optimization of readout RF pulse length can be disregarded in CEST imaging protocol.
關聯 Scientific Reports, 5, 15062
資料類型 article
DOI http://dx.doi.org/10.1038/srep15062
dc.contributor 應物所
dc.creator (作者) Huang, Sheng-Min;Jan, Meei-Ling;Liang, Hsin-Chin;Chang, Chia-Hao;Wu, Yi-Chun;Tsai, Shang-Yueh;Wang, Fu-Nien
dc.creator (作者) 蔡尚岳zh_TW
dc.date (日期) 2015-10
dc.date.accessioned 25-Nov-2015 16:37:06 (UTC+8)-
dc.date.available 25-Nov-2015 16:37:06 (UTC+8)-
dc.date.issued (上傳時間) 25-Nov-2015 16:37:06 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/79425-
dc.description.abstract (摘要) Chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) is capable of both microenvironment and molecular imaging. The optimization of scanning parameters is important since the CEST effect is sensitive to factors such as saturation power and field homogeneity. The aim of this study was to determine if the CEST effect would be altered by changing the length of readout RF pulses. Both theoretical computer simulation and phantom experiments were performed to examine the influence of readout RF pulses. Our results showed that the length of readout RF pulses has unremarkable impact on the Z-spectrum and CEST effect in both computer simulation and phantom experiment. Moreover, we demonstrated that multiple refocusing RF pulses used in rapid acquisition with relaxation enhancement (RARE) sequence induced no obvious saturation transfer contrast. Therefore, readout RF pulse has negligible effect on CEST Z-spectrum and the optimization of readout RF pulse length can be disregarded in CEST imaging protocol.
dc.format.extent 747234 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Scientific Reports, 5, 15062
dc.title (題名) Investigation of Readout RF Pulse Impact on the Chemical Exchange Saturation Transfer Spectrum
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1038/srep15062
dc.doi.uri (DOI) http://dx.doi.org/10.1038/srep15062