| dc.contributor | 神科所 | |
| dc.creator (作者) | Liu, B.R.;Chen, H.H.;Chan, M.H.;Huang, Y.W.;Aronstam, R.S;Lee, H.J.* | |
| dc.date (日期) | 2015 | |
| dc.date.accessioned | 14-Jan-2016 17:57:16 (UTC+8) | - |
| dc.date.available | 14-Jan-2016 17:57:16 (UTC+8) | - |
| dc.date.issued (上傳時間) | 14-Jan-2016 17:57:16 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/80587 | - |
| dc.description.abstract (摘要) | Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems. | |
| dc.format.extent | 107 bytes | - |
| dc.format.mimetype | text/html | - |
| dc.relation (關聯) | Journal of Nanoscience and Nanotechnology, 15, 2067-2078. | |
| dc.title (題名) | Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1166/jnn.2015.9148 | |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1166/jnn.2015.9148 | |
