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題名 阿朴嗎啡對中樞神經激胺的影響
Effects of apomorphine on central serotonergic system作者 王豐彬
Wang, Feng-Bin貢獻者 李小媛
Li, Xiao-Yuan
王豐彬
Wang, Feng-Bin關鍵詞 心理學
PSYCHIATRY
PSYCHOLOGY日期 1984 上傳時間 5-May-2016 17:24:27 (UTC+8) 摘要 以高壓液態色層分析(HPLC)螢光測定生化分析同時量測背側縫合核及紋狀體中Tryp
序言 壹 論文摘要 參 第一章 導論1 第一節 文獻探討1 第二節 研究目的8 第二章 研究方法11 第一節 實驗動物11 第二節 藥品11 第三節 儀器設備－－HPLC介紹 12 第四節 手術－－腦部注射14 第五節 組織切取20 第六節 統計方法21 第三章 實驗與結果23 第一節 APO對5-HT影響的詳細藥理機構23 第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色24 第三節 GABA在APO對5-HT影響中可能扮演的角色34 第四章 討論49 第一節 APO對5-HT影響的詳細藥理機構49 第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色50 第三節 GABA在APO對5-HT影響中可能扮演的角色52 第四節 APO對5-HT影響的行為含意53 第五章 結論55 參考文獻57 名詞對照表67 圖表目次 圖一 簡易神經通路4 圖二 外在標準的HPLC螢光測定生化分析圖15 圖三 背側縫合核的HPLC螢光測定生化分析圖16 圖四 尾狀核的HPLC螢光測定生化分析圖17 圖五 腹側縫合核的HPLC螢光測定生化分析圖18 圖六 海馬迴的HPLC螢光測定生化分析圖19 Table 1. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe 25 Table 2. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate 26 Table 3. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 27 Table 4. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocarnpus. 28 Table 5. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 31 Table 6. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 32 Table 7. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 35 Table 8 Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 36 Table 9. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 37 Table 10. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 38 Table 11. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 39 Table 12. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 40 Table 13. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in mdeian raphe. 41 Table 14. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in hippocampus. 42 Table 15. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 45 Table 16. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 46 Table 17. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 47 Table 18. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 48 附圖：Histology：Dye (Methylene Blue, 3mg/ml) infusion to caudate Neutral Red Staining. 65描述 碩士
國立政治大學
心理學系資料來源 http://thesis.lib.nccu.edu.tw/record/#B2002007106 資料類型 thesis dc.contributor.advisor 李小媛 zh_TW dc.contributor.advisor Li, Xiao-Yuan en_US dc.contributor.author (Authors) 王豐彬 zh_TW dc.contributor.author (Authors) Wang, Feng-Bin en_US dc.creator (作者) 王豐彬 zh_TW dc.creator (作者) Wang, Feng-Bin en_US dc.date (日期) 1984 en_US dc.date.accessioned 5-May-2016 17:24:27 (UTC+8) - dc.date.available 5-May-2016 17:24:27 (UTC+8) - dc.date.issued (上傳時間) 5-May-2016 17:24:27 (UTC+8) - dc.identifier (Other Identifiers) B2002007106 en_US dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/92142 - dc.description (描述) 碩士 zh_TW dc.description (描述) 國立政治大學 zh_TW dc.description (描述) 心理學系 zh_TW dc.description.abstract (摘要) 以高壓液態色層分析(HPLC)螢光測定生化分析同時量測背側縫合核及紋狀體中Tryp zh_TW dc.description.abstract (摘要) 序言 壹 論文摘要 參 第一章 導論1 第一節 文獻探討1 第二節 研究目的8 第二章 研究方法11 第一節 實驗動物11 第二節 藥品11 第三節 儀器設備－－HPLC介紹 12 第四節 手術－－腦部注射14 第五節 組織切取20 第六節 統計方法21 第三章 實驗與結果23 第一節 APO對5-HT影響的詳細藥理機構23 第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色24 第三節 GABA在APO對5-HT影響中可能扮演的角色34 第四章 討論49 第一節 APO對5-HT影響的詳細藥理機構49 第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色50 第三節 GABA在APO對5-HT影響中可能扮演的角色52 第四節 APO對5-HT影響的行為含意53 第五章 結論55 參考文獻57 名詞對照表67 圖表目次 圖一 簡易神經通路4 圖二 外在標準的HPLC螢光測定生化分析圖15 圖三 背側縫合核的HPLC螢光測定生化分析圖16 圖四 尾狀核的HPLC螢光測定生化分析圖17 圖五 腹側縫合核的HPLC螢光測定生化分析圖18 圖六 海馬迴的HPLC螢光測定生化分析圖19 Table 1. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe 25 Table 2. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate 26 Table 3. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 27 Table 4. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocarnpus. 28 Table 5. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 31 Table 6. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 32 Table 7. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 35 Table 8 Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 36 Table 9. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 37 Table 10. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 38 Table 11. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 39 Table 12. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 40 Table 13. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in mdeian raphe. 41 Table 14. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in hippocampus. 42 Table 15. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 45 Table 16. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 46 Table 17. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 47 Table 18. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 48 附圖：Histology：Dye (Methylene Blue, 3mg/ml) infusion to caudate Neutral Red Staining. 65 - dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#B2002007106 en_US dc.subject (關鍵詞) 心理學 zh_TW dc.subject (關鍵詞) PSYCHIATRY en_US dc.subject (關鍵詞) PSYCHOLOGY en_US dc.title (題名) 阿朴嗎啡對中樞神經激胺的影響 zh_TW dc.title (題名) Effects of apomorphine on central serotonergic system en_US dc.type (資料類型) thesis en_US
