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題名 Combination therapy for chronic hepatitis B: The future and beyond
作者 林志陵
Lin, Chih-Lin
貢獻者 心理學系
日期 2018-08
上傳時間 24-Jul-2018 16:46:02 (UTC+8)
摘要 To the Editor:We read with great interest the article entitled “Phase IV randomized clinical study: Peginterferon alfa-2a with adefovir or entecavir pre-therapy for HBeAg-positive chronic hepatitis B.” by Hsu et al. in the December 2017 online edition.1 Over the past decades, antiviral therapies have dramatically improved long-term outcomes of chronic hepatitis B (CHB). For HBeAg-positive patients, early HBeAg seroconversion is an important treatment end point for a promising outcome. Through immune modulatory effect, pegylated interferon (PEG-IFN) achieved higher rates of HBeAg seroconversion than nucleos(t)ide analogues (NA). However, the response rate of PEG-IFN is unsatisfactory. Therefore, combination therapies may have potential benefits.
關聯 JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 117(8), 745-746
資料類型 article
DOI https://doi.org/10.1016/j.jfma.2018.04.006
dc.contributor 心理學系-
dc.creator (作者) 林志陵zh_TW
dc.creator (作者) Lin, Chih-Linen_US
dc.date (日期) 2018-08-
dc.date.accessioned 24-Jul-2018 16:46:02 (UTC+8)-
dc.date.available 24-Jul-2018 16:46:02 (UTC+8)-
dc.date.issued (上傳時間) 24-Jul-2018 16:46:02 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/118861-
dc.description.abstract (摘要) To the Editor:We read with great interest the article entitled “Phase IV randomized clinical study: Peginterferon alfa-2a with adefovir or entecavir pre-therapy for HBeAg-positive chronic hepatitis B.” by Hsu et al. in the December 2017 online edition.1 Over the past decades, antiviral therapies have dramatically improved long-term outcomes of chronic hepatitis B (CHB). For HBeAg-positive patients, early HBeAg seroconversion is an important treatment end point for a promising outcome. Through immune modulatory effect, pegylated interferon (PEG-IFN) achieved higher rates of HBeAg seroconversion than nucleos(t)ide analogues (NA). However, the response rate of PEG-IFN is unsatisfactory. Therefore, combination therapies may have potential benefits.en_US
dc.format.extent 155982 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 117(8), 745-746-
dc.title (題名) Combination therapy for chronic hepatitis B: The future and beyonden_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1016/j.jfma.2018.04.006-
dc.doi.uri (DOI) https://doi.org/10.1016/j.jfma.2018.04.006-