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題名 PSLCNN: Protein Subcellular Localization Prediction for Eukaryotes and Prokaryotes Using Deep Learning
作者 張家銘
Chang, Jia-Ming
Chang, Che-Yu
Hsu, Tz-Wei
貢獻者 資科系
關鍵詞 Deep learning ; protein localization ; convolutional neural networks
日期 2019-11
上傳時間 27-Oct-2020 13:48:28 (UTC+8)
摘要 Many machine learning methods have been used to predict prokaryotic and eukaryotic protein subcellular localization. As most algorithms involve specific feature engineering, we carry out prediction using the feature-free property of deep learning methods. We present PSLCNN, a model using deep neural networks to predict protein subcellular localization for eukaryotes and prokaryotes. Only sequence information is needed (FASTA format). The model uses 1D convolution and predicts where the query localizes. It was trained and tested on an un-redundant dataset from the latest UniProt release, only for data with experimental annotation. Compared with the state-of-the-art tools, PSLCNN achieves the best performance for prokaryotes and is comparable for eukaryotes. We have also implemented a free PSLCNN web service available at https://github.com/changlabtw/PSLCNN.
關聯 International Conference on Technologies and Applications of Artificial Intelligence, Taiwanese Association for Artificial Intelligence
資料類型 conference
dc.contributor 資科系
dc.creator (作者) 張家銘
dc.creator (作者) Chang, Jia-Ming
dc.creator (作者) Chang, Che-Yu
dc.creator (作者) Hsu, Tz-Wei
dc.date (日期) 2019-11
dc.date.accessioned 27-Oct-2020 13:48:28 (UTC+8)-
dc.date.available 27-Oct-2020 13:48:28 (UTC+8)-
dc.date.issued (上傳時間) 27-Oct-2020 13:48:28 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/132232-
dc.description.abstract (摘要) Many machine learning methods have been used to predict prokaryotic and eukaryotic protein subcellular localization. As most algorithms involve specific feature engineering, we carry out prediction using the feature-free property of deep learning methods. We present PSLCNN, a model using deep neural networks to predict protein subcellular localization for eukaryotes and prokaryotes. Only sequence information is needed (FASTA format). The model uses 1D convolution and predicts where the query localizes. It was trained and tested on an un-redundant dataset from the latest UniProt release, only for data with experimental annotation. Compared with the state-of-the-art tools, PSLCNN achieves the best performance for prokaryotes and is comparable for eukaryotes. We have also implemented a free PSLCNN web service available at https://github.com/changlabtw/PSLCNN.
dc.format.extent 937146 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) International Conference on Technologies and Applications of Artificial Intelligence, Taiwanese Association for Artificial Intelligence
dc.subject (關鍵詞) Deep learning ; protein localization ; convolutional neural networks
dc.title (題名) PSLCNN: Protein Subcellular Localization Prediction for Eukaryotes and Prokaryotes Using Deep Learning
dc.type (資料類型) conference