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題名 Dopamine receptor antagonists impair place conditioning after acute stress in rats
作者 Liao, Ruey-Ming
Shen, IYing-Ling
Chen, Yao-Chu
廖瑞銘
貢獻者 國立政治大學心理學系
日期 2010-02
上傳時間 29-Dec-2008 15:33:48 (UTC+8)
摘要 An immediate and robust release of dopamine appears in the brain under an acute stressor, but the functional role of dopamine under stress remains elusive. We recently showed conditioned place preference (CPP) induced by the acute application of a stressor such as being placed on an elevated stand or immobilized in a restraint holder. This study tested whether dopamine is involved in such CPP. The selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively, were injected before stressor manipulation. The doses of SCH23390 (0.025 and 0.05 mg/kg) and raclopride (0.05 and 0.1 mg/kg) used to test for stressor-induced CPP were verified to be ineffective on spontaneous locomotor activity. The results showed that both drugs attenuated the development of stressor-induced CPP. Such a CPP blocking effect by pretreatment of dopamine receptor antagonist was true for either kind of stressor manipulated. These findings indicate that an acute stressor can facilitate a follow-up place conditioning, and that dopamine is involved in the present type of CPP formation.
關聯 Behavioural Pharmacology, 21, 77-82
資料類型 article
DOI http://dx.doi.org/10.1097/FBP.0b013e3283359f20
dc.contributor 國立政治大學心理學系-
dc.creator (作者) Liao, Ruey-Mingen_US
dc.creator (作者) Shen, IYing-Lingen_US
dc.creator (作者) Chen, Yao-Chuen_US
dc.creator (作者) 廖瑞銘zh_TW
dc.date (日期) 2010-02en_US
dc.date.accessioned 29-Dec-2008 15:33:48 (UTC+8)-
dc.date.available 29-Dec-2008 15:33:48 (UTC+8)-
dc.date.issued (上傳時間) 29-Dec-2008 15:33:48 (UTC+8)-
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/19806-
dc.description.abstract (摘要) An immediate and robust release of dopamine appears in the brain under an acute stressor, but the functional role of dopamine under stress remains elusive. We recently showed conditioned place preference (CPP) induced by the acute application of a stressor such as being placed on an elevated stand or immobilized in a restraint holder. This study tested whether dopamine is involved in such CPP. The selective dopamine D1 and D2 receptor antagonists, SCH23390 and raclopride, respectively, were injected before stressor manipulation. The doses of SCH23390 (0.025 and 0.05 mg/kg) and raclopride (0.05 and 0.1 mg/kg) used to test for stressor-induced CPP were verified to be ineffective on spontaneous locomotor activity. The results showed that both drugs attenuated the development of stressor-induced CPP. Such a CPP blocking effect by pretreatment of dopamine receptor antagonist was true for either kind of stressor manipulated. These findings indicate that an acute stressor can facilitate a follow-up place conditioning, and that dopamine is involved in the present type of CPP formation.-
dc.format application/en_US
dc.language enen_US
dc.language en-USen_US
dc.language.iso en_US-
dc.relation (關聯) Behavioural Pharmacology, 21, 77-82en_US
dc.title (題名) Dopamine receptor antagonists impair place conditioning after acute stress in ratsen_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1097/FBP.0b013e3283359f20en_US
dc.doi.uri (DOI) http://dx.doi.org/10.1097/FBP.0b013e3283359f20en_US