1. NCCU Academic Hub
  2. 學術產出
  3. College of Science
  4. Periodical Articles
  5. Item

學術產出-Periodical Articles

Article View/Open

Publication Export

Google ScholarTM

政大圖書館

Citation Infomation

  • No doi shows Citation Infomation
題名 Cellular Internalization of Quantum Dots Mediated by Cell-Penetrating
作者 詹銘煥
Chan,Ming-Huan
Liu,Betty Revon;Chiang,Huey-Jenn;Huang,Yue-Wern;Chan,Ming-Huan;Chen,Hwei-Hsien;Lee,Han-Jung
貢獻者 神科所
關鍵詞 Cell-penetrating peptides; pharmacological inhibitors; polyarginine; protein transduction; quantum dots
日期 2013.01
上傳時間 3-Dec-2013 18:20:32 (UTC+8)
摘要 Nanomaterials have been utilized in biomedical applications for many years because of their unique properties such as quantum confinement, surface plasmon resonance, and superparamagnetism. These applications are expected to advance diagnosis and therapeutics. Fluorescent nanomaterials, such as quantum dots (QDs), were exalted in biological imaging and tracking, and trended to replace protein-based probes. Our previous investigation indicated that cell-penetrating peptides (CPPs) are a promising delivery system that can translocate materials efficiently in a noncovalent manner. In this study, we demonstrate that arginine-rich CPPs can noncovalently complex with QDs and significantly raise efficiency of cellular entry. We further examined their mechanisms of cellular penetrations, subcellular localizations, and cytotoxicity. Importantly, CPP/QD complexes were not toxic at the level of efficient transduction. Collectively, our study provided an insight that CPPs can facilitate the delivery of nanomaterials into cells. Various compositions of CPPs are a major factor affecting uptake routes and efficiency for drug delivery applications.
關聯 Pharmaceutical Nanotechnology, 1(2), 151-161
資料類型 article
dc.contributor 神科所en_US
dc.creator (作者) 詹銘煥zh_TW
dc.creator (作者) Chan,Ming-Huanen_US
dc.creator (作者) Liu,Betty Revon;Chiang,Huey-Jenn;Huang,Yue-Wern;Chan,Ming-Huan;Chen,Hwei-Hsien;Lee,Han-Jung-
dc.date (日期) 2013.01en_US
dc.date.accessioned 3-Dec-2013 18:20:32 (UTC+8)-
dc.date.available 3-Dec-2013 18:20:32 (UTC+8)-
dc.date.issued (上傳時間) 3-Dec-2013 18:20:32 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/62104-
dc.description.abstract (摘要) Nanomaterials have been utilized in biomedical applications for many years because of their unique properties such as quantum confinement, surface plasmon resonance, and superparamagnetism. These applications are expected to advance diagnosis and therapeutics. Fluorescent nanomaterials, such as quantum dots (QDs), were exalted in biological imaging and tracking, and trended to replace protein-based probes. Our previous investigation indicated that cell-penetrating peptides (CPPs) are a promising delivery system that can translocate materials efficiently in a noncovalent manner. In this study, we demonstrate that arginine-rich CPPs can noncovalently complex with QDs and significantly raise efficiency of cellular entry. We further examined their mechanisms of cellular penetrations, subcellular localizations, and cytotoxicity. Importantly, CPP/QD complexes were not toxic at the level of efficient transduction. Collectively, our study provided an insight that CPPs can facilitate the delivery of nanomaterials into cells. Various compositions of CPPs are a major factor affecting uptake routes and efficiency for drug delivery applications.-
dc.format.extent 587019 bytes-
dc.format.mimetype application/pdf-
dc.language.iso en_US-
dc.relation (關聯) Pharmaceutical Nanotechnology, 1(2), 151-161en_US
dc.subject (關鍵詞) Cell-penetrating peptides; pharmacological inhibitors; polyarginine; protein transduction; quantum dotsen_US
dc.title (題名) Cellular Internalization of Quantum Dots Mediated by Cell-Penetratingen_US
dc.type (資料類型) articleen