| dc.contributor | 神科所 | en_US |
| dc.creator (作者) | Chan, Ming-Huan ; Lee, Chia-Chi ; Lin, Bih-Fen ; Wu, Chia-Yen ; Chen, Hwei-Hsien | en_US |
| dc.creator (作者) | 詹銘煥 | zh_TW |
| dc.date (日期) | 2012.12 | en_US |
| dc.date.accessioned | 9-Apr-2014 17:17:42 (UTC+8) | - |
| dc.date.available | 9-Apr-2014 17:17:42 (UTC+8) | - |
| dc.date.issued (上傳時間) | 9-Apr-2014 17:17:42 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/65230 | - |
| dc.description.abstract (摘要) | Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances in both humans and animals. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in acute toluene-induced behavioral manifestations. Activation of type 5 metabotropic glutamate receptors (mGluR5) attenuates behavioral responses induced by NMDA receptor blockade. The present study elucidated the role of mGluR5 on toluene-induced behavioral and hypothermic responses. Male Sprague–Dawley rats received the mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) or antagonist 6-methyl-2-[phenylethynyl]-pyridine (MPEP) prior to toluene administration. Rotarod test, step-down inhibitory avoidance learning task, and rectal temperature were monitored. Pretreatment of CHPG and MPEP attenuated and potentiated these toluene-induced responses, respectively. In addition, the inhibitory effects of CHPG on toluene-induced motor incoordination, learning impairment, and hypothermia were reversed by the protein kinase C (PKC) inhibitor chelerythrine chloride. These findings suggest that mGluR5 may modulate the neural circuits responsible for motor incoordination, learning impairment, and hypothermic action of toluene through a PKC-dependent signal transduction pathway. | en_US |
| dc.format.extent | 350768 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en_US | - |
| dc.relation (關聯) | Pharmacology, biochemistry and behavior,103(2), 418-424 | en_US |
| dc.source.uri (資料來源) | http://dx.doi.org/10.1016/j.pbb.2012.09.019 | en_US |
| dc.subject (關鍵詞) | Toluene; mGluR5; NMDA receptor; Motor coordination; Learning; Hypothermia | en_US |
| dc.title (題名) | Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats | en_US |
| dc.type (資料類型) | article | en |
