| dc.contributor | 神科所 | en_US |
| dc.creator (作者) | 詹銘煥 | zh_TW |
| dc.creator (作者) | Chan, Ming-Huan ; Chung, Shiang-Sheng ; Stoker, Astrid K. ; Markou, Athina ; Chen, Hwei-Hsien | en_US |
| dc.date (日期) | 2012.12 | en_US |
| dc.date.accessioned | 6-May-2014 16:41:25 (UTC+8) | - |
| dc.date.available | 6-May-2014 16:41:25 (UTC+8) | - |
| dc.date.issued (上傳時間) | 6-May-2014 16:41:25 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/65828 | - |
| dc.description.abstract (摘要) | Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances, including motor incoordination and cognitive impairment. Toluene alters the function of a large number of receptors and ion channels. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in toluene-induced behavioral manifestations. The present study determined the effects of various toluene doses on motor coordination, recognition memory, body temperature, and intracranial self-stimulation (ICSS) thresholds in mice. Additionally, the effects of sarcosine on the behavioral and physiological effects induced by toluene were evaluated. Sarcosine may reverse toluene-induced behavioral manifestations by acting as an NMDA receptor co-agonist and by inhibiting the effects of the type I glycine transporter (GlyT1). Mice were treated with toluene alone or combined with sarcosine pretreatment and assessed for rotarod performance, object recognition memory, rectal temperature, and ICSS thresholds. Toluene dose-dependently induced motor incoordination, recognition memory impairment, and hypothermia and lowered ICSS thresholds. Sarcosine pretreatment reversed toluene-induced changes in rotarod performance, novel object recognition, and rectal temperature but not ICSS thresholds. These findings suggest that the sarcosine-induced potentiation of NMDA receptors may reverse motor incoordination, memory impairment, and hypothermia but not the enhancement of brain stimulation reward function associated with toluene exposure. Sarcosine may be a promising compound to prevent acute toluene intoxications by occupational or intentional exposure. | en_US |
| dc.format.extent | 293945 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en_US | - |
| dc.relation (關聯) | Toxicology and Applied Pharmacology, 265(2), 158-165 | en_US |
| dc.subject (關鍵詞) | Toluene; Motor coordination; Recognition memory; Body temperature; Intracranial self-stimulation | en_US |
| dc.title (題名) | Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice | en_US |
| dc.type (資料類型) | article | en |
