| dc.contributor | 心理系 | - |
| dc.creator (作者) | Ko, Mei-Chuan | - |
| dc.creator (作者) | 柯美全 | zh_TW |
| dc.creator (作者) | Naughton, Norah N. | en_US |
| dc.date (日期) | 2009-05 | - |
| dc.date.accessioned | 24-Aug-2015 10:54:50 (UTC+8) | - |
| dc.date.available | 24-Aug-2015 10:54:50 (UTC+8) | - |
| dc.date.issued (上傳時間) | 24-Aug-2015 10:54:50 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/77934 | - |
| dc.description.abstract (摘要) | Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors. Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie, hyperalgesia and antinociception) in rodents. However, the pharmacological profile of intrathecal N/OFQ is not fully known in primates. The aim of this study was to investigate behavioral effects of intrathecal N/OFQ over a wide dose range and to compare its effects with ligands known to produce hyperalgesia or antinociception in monkeys. Intrathecal N/OFQ from 1 fmol to 1 nmol did not produce any hyperalgesic or scratching responses. In contrast, intrathecal substance P 100 nmol produced hyperalgesia, and intrathecal DAMGO 10 nmol produced antinociception. At the dose range between 10 nmol and 1 μmol, intrathecal N/OFQ dose-dependently produced thermal antinociception against a noxious stimulus in 2 intensities. More importantly, N/OFQ in combined with intrathecal morphine dose-dependently potentiated morphine-induced antinociception without inhibiting morphine-induced itch/scratching. Taken together, this study is the first to provide a unique functional profile of intrathecal N/OFQ over a wide dose range in primates. Intrathecal N/OFQ produces thermal antinociception without anti-morphine actions or scratching responses, indicating that N/OFQ or NOP receptor agonists represent a promising target as spinal analgesics. | - |
| dc.format.extent | 226808 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | The Journal of Pain, 10(5), 509-516 | - |
| dc.subject (關鍵詞) | Spinal cord;analgesia;NOP receptors;substance P;thermal hyperalgesia | - |
| dc.title (題名) | Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys | - |
| dc.type (資料類型) | article | en |
| dc.identifier.doi (DOI) | 10.1016/j.jpain.2008.11.006 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1016/j.jpain.2008.11.006 | - |
